Preserved endothelial vasomotion and fibrinolytic function in patients with acute stent thrombosis or in-stent restenosis

Stanley Chia, Ian L Megson, Christopher A Ludlam, Keith A Fox, David E Newby

Research output: Contribution to journalArticlepeer-review

Abstract

INTRODUCTION: Acute stent thrombosis and in-stent restenosis are serious complications of percutaneous coronary intervention (PCI) and may be associated with vascular or platelet abnormalities. We aimed to assess endothelium-dependent vasomotion, endogenous fibrinolysis and platelet function in patients with acute stent thrombosis or in-stent restenosis.

MATERIALS AND METHODS: Thirty-six subjects were enrolled into four groups: acute stent thrombosis, in-stent restenosis, uncomplicated PCI with stent implantation and healthy matched controls. Forearm blood flow was measured using bilateral venous occlusion plethysmography during intra-brachial acetylcholine, substance P and sodium nitroprusside infusion. Venous blood samples were withdrawn for estimation of plasma fibrinolytic variables and platelet aggregometry.

RESULTS: Acetylcholine, substance P and sodium nitroprusside caused dose-dependent increases in blood flow (P < 0.001) and substance P caused a dose-dependent increase in tissue-type plasminogen activator (t-PA) release (P < 0.001) in all groups. Thrombin, collagen, adenosine diphosphate (ADP) and the thromboxane A2 analogue, U46619, caused dose-dependent platelet aggregation (P < 0.001) in all groups. There were no significant between group differences in these responses except that, in keeping with aspirin therapy, collagen-induced platelet aggregation was impaired in patient groups compared with healthy controls (P < 0.01). Post-hoc analysis demonstrated a significant impairment of acute t-PA release in current smokers compared to non-smokers (P < 0.05).

CONCLUSIONS: Despite previous reports suggesting impaired vascular function, endothelium-dependent vasomotion, endogenous fibrinolysis and platelet aggregation do not appear to play a major role in the pathogenesis of acute stent thrombosis or in-stent restenosis.

Original languageEnglish
Pages (from-to)343-9
Number of pages7
JournalThrombosis Research
Volume111
Issue number6
Publication statusPublished - 2003

Keywords

  • Acetylcholine
  • Aged
  • Case-Control Studies
  • Coronary Restenosis
  • Coronary Thrombosis
  • Endothelium, Vascular
  • Female
  • Fibrinolysis
  • Humans
  • Male
  • Middle Aged
  • Nitroprusside
  • Platelet Aggregation
  • Regional Blood Flow
  • Stents
  • Substance P

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