PressureCap: An endoscopic sensor capsule for real-time gastrointestinal pressure monitoring

Vasileios Mitrakos, Gerard Cummins*, Faulk J. Tauber, Benjamin F. Cox, Sumanth Kumar Pavuluri, Graham Wood, Mark A. Potter, Eddie Clutton, Sandy Cochran, Thomas Speck, Philip J. W. Hands, Marc P.Y. Desmulliez

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Functional gastrointestinal (GI) disease associated with abnormal GI motility has an adverse impact on the quality of life of those affected. High-resolution manometry has improved the diagnosis of these conditions, enabling motility measurement, but these tools are limited in that they cannot access the entire length of the GI tract. Other solutions, such as the SmartPill ingestible motility capsule, only measure the transit times between the regions of the GI tract and provide information on the luminal component of GI pressure. Measuring both luminal and contractile pressure caused by peristalsis would improve the diagnosis of abnormal motility. Here, we report an ingestible capsule encapsulated with a flexible pressure sensor array. The capsule can detect changes in both contractile and luminal GI pressure in an in vitro peristaltic tissue phantom and in porcine animal models. These findings promise high-resolution, sensitive, multisite pressure measurements currently not possible with other ingestible motility capsules.
Original languageEnglish
Article number100325
Issue number5
Early online date19 Mar 2024
Publication statusPublished - 17 May 2024

Keywords / Materials (for Non-textual outputs)

  • DTI-4: Validate
  • capsule endoscopy
  • flexible sensor
  • gastrointestinal motility
  • pressure sensor


Dive into the research topics of 'PressureCap: An endoscopic sensor capsule for real-time gastrointestinal pressure monitoring'. Together they form a unique fingerprint.

Cite this