Presynaptic NMDA receptors: Are they dendritic receptors in disguise?

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The N-methyl-d-aspartate (NMDA) receptor plays an essential role in excitatory transmission, synaptic integration, and learning and memory. In the classical view, postsynaptic NMDA receptors act as canonical coincidence detectors providing a 'molecular switch' for the induction of various forms of short- and long-term synaptic plasticity. Over the past twenty years there has been accumulating evidence to suggest that NMDA receptors are also expressed presynaptically and are involved in the regulation of synaptic transmission and specific forms of activity-dependent plasticity in developing neural circuits. However, the existence of presynaptic NMDA receptors remains a contentious issue. In this review, I will discuss the criteria required for identifying functional presynaptic receptors, novel methods for probing NMDA receptor function, and recent evidence to suggest that NMDA receptors are expressed at presynaptic sites in a target-specific manner.
Original languageEnglish
Pages (from-to)4-9
Number of pages6
JournalBrain Research Bulletin
Publication statusPublished - Apr 2013


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