Preterm birth and infant diurnal cortisol regulation

David Q.  Stoye; James P Boardman; Clive Osmond; Gemma Sullivan; Gillian J. Lamb; Gill S. Black; Natalie Z M Homer; Nina  Nelson; Elvar  Theodorsson; Rebecca M Reynolds; Evalotte  Mörelius

doi:10.1136/archdischild-2021-323296

Preterm birth and infant diurnal cortisol regulation

David Q. Stoye, James P Boardman, Clive Osmond, Gemma Sullivan, Gillian J. Lamb, Gill S. Black, Natalie Z M Homer, Nina Nelson, Elvar Theodorsson, Rebecca M Reynolds^*, Evalotte Mörelius

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Background: Hypothalamic-pituitary-adrenal (HPA) axis adaptation is a potential mechanism linking early life exposures with later adverse health. This study tested the hypothesis that preterm birth is associated with adaptation of diurnal cortisol regulation across infancy.

Methods: A secondary analysis was conducted of saliva cortisol measured morning, midday and evening, monthly, across infancy, as part of a birth cohort conducted in Linköping, Sweden. Diurnal cortisol regulation of infants born extremely preterm (n=24), very preterm (n=27) and at term (n=130) were compared across infancy through random coefficients regression models.

Results: Compared to infants born at term, infants born extremely preterm (-17.2%, 95% CI: -30.7 to -1.2), but not very preterm (1.7%, -14.1 to 20.4), had a flattened diurnal slope across infancy.

Conclusions: Extremely preterm birth is associated with a flattened diurnal slope in infancy. This pattern of cortisol regulation could contribute to adverse metabolic and neurodevelopmental phenotypes observed in this population.

Original language	English
Journal	Archives of Disease in Childhood
DOIs	https://doi.org/10.1136/archdischild-2021-323296
Publication status	Published - 14 Mar 2022

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10.1136/archdischild-2021-323296

Preterm birth and infant diurnal cortisol regulationAccepted author manuscript, 148 KBLicence: Creative Commons: Attribution Non-Commercial (CC-BY-NC)

Research Excellence Award Number 3
Baker, A.
UK-based charities
1/04/19 → 31/03/24
Project: Research

Edinburgh Clinical Research Facility Mass Spectrometry Core in the QMRI
Natalie Homer (Manager), Scott Denham (Other) & Jo Simpson (Other)
Centre for Cardiovascular Science
Facility/equipment: Facility

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@article{f5af1d721cfa4e0f9248ac058b75f6f4,

title = "Preterm birth and infant diurnal cortisol regulation",

abstract = "Background: Hypothalamic-pituitary-adrenal (HPA) axis adaptation is a potential mechanism linking early life exposures with later adverse health. This study tested the hypothesis that preterm birth is associated with adaptation of diurnal cortisol regulation across infancy. Methods: A secondary analysis was conducted of saliva cortisol measured morning, midday and evening, monthly, across infancy, as part of a birth cohort conducted in Link{\"o}ping, Sweden. Diurnal cortisol regulation of infants born extremely preterm (n=24), very preterm (n=27) and at term (n=130) were compared across infancy through random coefficients regression models.Results: Compared to infants born at term, infants born extremely preterm (-17.2%, 95% CI: -30.7 to -1.2), but not very preterm (1.7%, -14.1 to 20.4), had a flattened diurnal slope across infancy. Conclusions: Extremely preterm birth is associated with a flattened diurnal slope in infancy. This pattern of cortisol regulation could contribute to adverse metabolic and neurodevelopmental phenotypes observed in this population. ",

author = "Stoye, {David Q.} and Boardman, {James P} and Clive Osmond and Gemma Sullivan and Lamb, {Gillian J.} and Black, {Gill S.} and Homer, {Natalie Z M} and Nina Nelson and Elvar Theodorsson and Reynolds, {Rebecca M} and Evalotte M{\"o}relius",

note = "Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.",

year = "2022",

month = mar,

day = "14",

doi = "10.1136/archdischild-2021-323296",

language = "English",

journal = "Archives of Disease in Childhood",

issn = "0003-9888",

publisher = "BMJ Publishing Group Ltd",

}

TY - JOUR

T1 - Preterm birth and infant diurnal cortisol regulation

AU - Stoye, David Q.

AU - Boardman, James P

AU - Osmond, Clive

AU - Sullivan, Gemma

AU - Lamb, Gillian J.

AU - Black, Gill S.

AU - Homer, Natalie Z M

AU - Nelson, Nina

AU - Theodorsson, Elvar

AU - Reynolds, Rebecca M

AU - Mörelius, Evalotte

PY - 2022/3/14

Y1 - 2022/3/14

N2 - Background: Hypothalamic-pituitary-adrenal (HPA) axis adaptation is a potential mechanism linking early life exposures with later adverse health. This study tested the hypothesis that preterm birth is associated with adaptation of diurnal cortisol regulation across infancy. Methods: A secondary analysis was conducted of saliva cortisol measured morning, midday and evening, monthly, across infancy, as part of a birth cohort conducted in Linköping, Sweden. Diurnal cortisol regulation of infants born extremely preterm (n=24), very preterm (n=27) and at term (n=130) were compared across infancy through random coefficients regression models.Results: Compared to infants born at term, infants born extremely preterm (-17.2%, 95% CI: -30.7 to -1.2), but not very preterm (1.7%, -14.1 to 20.4), had a flattened diurnal slope across infancy. Conclusions: Extremely preterm birth is associated with a flattened diurnal slope in infancy. This pattern of cortisol regulation could contribute to adverse metabolic and neurodevelopmental phenotypes observed in this population.

AB - Background: Hypothalamic-pituitary-adrenal (HPA) axis adaptation is a potential mechanism linking early life exposures with later adverse health. This study tested the hypothesis that preterm birth is associated with adaptation of diurnal cortisol regulation across infancy. Methods: A secondary analysis was conducted of saliva cortisol measured morning, midday and evening, monthly, across infancy, as part of a birth cohort conducted in Linköping, Sweden. Diurnal cortisol regulation of infants born extremely preterm (n=24), very preterm (n=27) and at term (n=130) were compared across infancy through random coefficients regression models.Results: Compared to infants born at term, infants born extremely preterm (-17.2%, 95% CI: -30.7 to -1.2), but not very preterm (1.7%, -14.1 to 20.4), had a flattened diurnal slope across infancy. Conclusions: Extremely preterm birth is associated with a flattened diurnal slope in infancy. This pattern of cortisol regulation could contribute to adverse metabolic and neurodevelopmental phenotypes observed in this population.

U2 - 10.1136/archdischild-2021-323296

DO - 10.1136/archdischild-2021-323296

M3 - Article

SN - 0003-9888

JO - Archives of Disease in Childhood

JF - Archives of Disease in Childhood

ER -

Preterm birth and infant diurnal cortisol regulation

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Projects

Research Excellence Award Number 3

Equipment

Edinburgh Clinical Research Facility Mass Spectrometry Core in the QMRI

Cite this