Prevalence and associated risk factors of mycobacterial infections in slaughter pigs from Mubende district in Uganda

Adrian Muwonge, Clovice Kankya, Jacques Godfroid, Berit Djonne, John Opuda-Asibo, Demelash Biffa, Takele Ayanaw, Musso Munyeme, Eystein Skjerve

Research output: Contribution to journalArticlepeer-review

Abstract

To date, the public health relevance of mycobacterial infections in pigs is not well investigated despite high risk of infection. Recently, there has been a documented increase in opportunistic infections and risk of acquiring opportunistic mycobacterial infections in HIV/AIDS patients in Mubende district; unfortunately, there has been no published information on the epidemiology of mycobacterial infections in this area. This study was carried out between September 2008 and February 2009. Investigations were done to assess the prevalence and associated risk factors of mycobacterial infections in slaughtered pigs in Mubende district of Uganda. A total of 997 pigs (53.7% male and 46.3% female) from 31 different slaughterhouses were examined for the presence of lesions compatible with TB and mycobacterial infections. Pathologic tissue specimens were collected for culturing and isolation of mycobacteria. A cross-sectional technique was used based on convenient visits to slaughterhouses but random selection of individual slaughtered pigs for a detailed post-mortem inspection on a daily basis. The results reflected a 9.3% and 3.1% (95% CI) prevalence of Mycobacterium species based on necropsy examinations and culture isolation, respectively. The highest prevalence of mycobacterial infection was recorded in Buwekula County (the mixed agro-zone) whilst the lowest was in Kassanda County (pastoral zone). A multivariable logistical regression analysis identified age (P <or = 0.001) and sex (P <or = 0.05) as risk factors for mycobacterial infections in pigs. Post-estimation statistics of the regression model evaluation and validation fit it well into the data (HL, chi (2) = 5.9; P = 0.69 for necropsy, HL chi (2) = 2.9; P = 0.94 for culturing). This study documented a high prevalence of mycobacterial infections in slaughter pigs in Mubende district. The fact that pigs and human often share common housing and environment poses a high risk of zoonotic transmission. This then warrants further molecular investigation to identify the specific Mycobacterium species and their public health importance in this area.
Original languageEnglish
Pages (from-to)905-13
Number of pages9
JournalTropical Animal Health and Production
Volume42
Issue number5
DOIs
Publication statusPublished - Jun 2010

Keywords

  • Swine
  • Cross-Sectional Studies
  • Animals
  • Abattoirs
  • Risk Factors
  • Mycobacterium Infections
  • Uganda
  • Swine Diseases
  • Male
  • Female
  • Prevalence

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