Prevalence, incidence, and clinical characteristics of hepatitis G virus/GB virus C infection in Scottish blood donors

C S Blair, F Davidson, C Lycett, D M McDonald, G H Haydon, P L Yap, P C Hayes, P Simmonds, J Gillon

Research output: Contribution to journalArticlepeer-review

Abstract

The prevalence, incidence, clinical features, and natural history of hepatitis G virus (HGV) or GB virus C (GBV-C) were investigated in a non-remunerated blood donor population to determine its clinical significance and its impact on blood safety. Of 1020 regular blood donors, 23 (2.25%) were positive for plasma HGV/GBV-C RNA. Alanine aminotransferase levels were lower than in uninfected donors (median, 20 IU/mL; 32 IU/mL in controls; P=.015). Clinical examination produced no other evidence for hepatitis or for shared nonhepatic diseases. Fifteen of 17 donors excreted HGV/GBV-C in saliva (mean level, 8x103 copies of RNA/mL). Testing of previous donations indicated an incidence of 170-200 new infections with HGV/GBV-C per 100,000 donor-years. The absence of further clinicopathologic data and the limitations of current polymerase chain reaction-based methods for screening suggests that it is neither necessary nor practical to commence screening.
Original languageEnglish
Pages (from-to)1779-82
Number of pages4
JournalThe Journal of Infectious Diseases
Volume178
Issue number6
DOIs
Publication statusPublished - Dec 1998

Keywords

  • Adult
  • Blood Donors
  • Blood Transfusion
  • Female
  • Flaviviridae
  • Hepacivirus
  • Hepatitis C
  • Hepatitis, Viral, Human
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Prevalence
  • RNA, Viral
  • Safety
  • Saliva
  • Scotland

Fingerprint

Dive into the research topics of 'Prevalence, incidence, and clinical characteristics of hepatitis G virus/GB virus C infection in Scottish blood donors'. Together they form a unique fingerprint.

Cite this