Prevalence of abnormal plasma liver enzymes in older people with Type 2 diabetes

on behalf of the Edinburgh Type 2 Diabetes Study investigators, J R Morling, M W J Strachan, P C Hayes, I Butcher, B M Frier, R M Reynolds, J F Price

Research output: Contribution to journalArticlepeer-review

Abstract

Diabet. Med. 29, 488-491 (2012) ABSTRACT: Aims  To determine the prevalence and distribution of abnormal plasma liver enzymes in a representative sample of older adults with Type 2 diabetes. Methods  Plasma concentrations of alanine aminotransferase, aspartate aminotransferase and γ-glutamyltransferase were measured in a randomly selected, population-based cohort of 1066 men and women aged 60-75 years with Type 2 diabetes (the Edinburgh Type 2 Diabetes Study). Results  Overall, 29.1% (95% CI 26.1-31.8) of patients had one or more plasma liver enzymes above the upper limit of the normal reference range. Only 10.1% of these patients had a prior history of liver disease and a further 12.4% reported alcohol intake above recommended limits. Alanine aminotransferase was the most commonly raised liver enzyme (23.1% of patients). The prevalence of abnormal liver enzymes was significantly higher in men (odds ratio 1.40, 95% CI 1.07-1.83), in the youngest 5-year age band (odds ratio 2.02, 95% CI 1.44-2.84), in patients with diabetes duration
Original languageEnglish
Pages (from-to)488-491
Number of pages4
JournalDiabetic Medicine
Volume29
Issue number4
DOIs
Publication statusPublished - 2012

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