Prevalence of influenza A (H1N1) seropositivity in unvaccinated healthcare workers in Scotland at the height of the global pandemic

Kate Smith; Pamela Warner; Linda J Williams; Walt E Adamson; S Vittal Katikireddi; Paul Dewart; William F Carman; Kate Templeton; Fiona C Denison; D Graham Mackenzie

doi:10.1155/2011/407505

Prevalence of influenza A (H1N1) seropositivity in unvaccinated healthcare workers in Scotland at the height of the global pandemic

Kate Smith, Pamela Warner, Linda J Williams, Walt E Adamson, S Vittal Katikireddi, Paul Dewart, William F Carman, Kate Templeton, Fiona C Denison, D Graham Mackenzie

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

We set out to identify the level of previous exposure to influenza A (H1N1) in unvaccinated healthcare workers (HCWs) at the peak of the pandemic outbreak in the UK, with control samples collected prior to the outbreak.
METHODS:
Cross-sectional study (seroprevalence assessed before and at pandemic peak, with questionnaire data collected at peak of outbreak) in HCWs in Scotland.
RESULTS:
The prevalence of seropositivity in 493 HCWs at pandemic peak was 10.3%, which was higher than the prepandemic level by 3.7 percentage points (95% CI 0.3% to 7.3%, P = 0.048). Seropositivity rates for frontline and nonfrontline HCWs were similar.
CONCLUSION:
At pandemic peak, only 10.3% of HCWs were seropositive for influenza A (H1N1), so the great majority were still susceptible to infection at the introduction of the vaccination programme. Few studies have reported on seroprevalence in unvaccinated and asymptomatic participants, so our findings may have relevance to the wider population.

Original language	English
Article number	407505
Journal	Journal of Environmental and Public Health
Volume	2011
DOIs	https://doi.org/10.1155/2011/407505
Publication status	Published - 2011

Keywords / Materials (for Non-textual outputs)

Adolescent
Adult
Aged
Antibodies, Viral
Cross-Sectional Studies
Health Personnel
Humans
Influenza A Virus, H1N1 Subtype
Influenza, Human
Logistic regression
Middle Aged
pandemic
PREVALENCE
SCOTLAND
Seroepidemiologic Studies
VACCINATION
Young Adult

Access to Document

10.1155/2011/407505

Prevalence of influenza A (H1N1) seropositivity in unvaccinated healthcare workers in Scotland at the height of the global pandemic
Copyright © 2011 Kate Smith et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Final published version, 501 KB

Cite this

Smith, K., Warner, P., Williams, L. J., Adamson, W. E., Katikireddi, S. V., Dewart, P., Carman, W. F., Templeton, K., Denison, F. C., & Mackenzie, D. G. (2011). Prevalence of influenza A (H1N1) seropositivity in unvaccinated healthcare workers in Scotland at the height of the global pandemic. Journal of Environmental and Public Health, 2011, [407505]. https://doi.org/10.1155/2011/407505

@article{8eaf10ae66b24f168b8645635edd36ef,

title = "Prevalence of influenza A (H1N1) seropositivity in unvaccinated healthcare workers in Scotland at the height of the global pandemic",

abstract = "We set out to identify the level of previous exposure to influenza A (H1N1) in unvaccinated healthcare workers (HCWs) at the peak of the pandemic outbreak in the UK, with control samples collected prior to the outbreak.METHODS:Cross-sectional study (seroprevalence assessed before and at pandemic peak, with questionnaire data collected at peak of outbreak) in HCWs in Scotland.RESULTS:The prevalence of seropositivity in 493 HCWs at pandemic peak was 10.3%, which was higher than the prepandemic level by 3.7 percentage points (95% CI 0.3% to 7.3%, P = 0.048). Seropositivity rates for frontline and nonfrontline HCWs were similar.CONCLUSION:At pandemic peak, only 10.3% of HCWs were seropositive for influenza A (H1N1), so the great majority were still susceptible to infection at the introduction of the vaccination programme. Few studies have reported on seroprevalence in unvaccinated and asymptomatic participants, so our findings may have relevance to the wider population.",

keywords = "Adolescent, Adult, Aged, Antibodies, Viral, Cross-Sectional Studies, Health Personnel, Humans, Influenza A Virus, H1N1 Subtype, Influenza, Human, Logistic regression, Middle Aged, pandemic, PREVALENCE, SCOTLAND, Seroepidemiologic Studies, VACCINATION, Young Adult",

author = "Kate Smith and Pamela Warner and Williams, {Linda J} and Adamson, {Walt E} and Katikireddi, {S Vittal} and Paul Dewart and Carman, {William F} and Kate Templeton and Denison, {Fiona C} and Mackenzie, {D Graham}",

year = "2011",

doi = "10.1155/2011/407505",

language = "English",

volume = "2011",

journal = "Journal of Environmental and Public Health",

issn = "1687-9805",

publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Prevalence of influenza A (H1N1) seropositivity in unvaccinated healthcare workers in Scotland at the height of the global pandemic

AU - Smith, Kate

AU - Warner, Pamela

AU - Williams, Linda J

AU - Adamson, Walt E

AU - Katikireddi, S Vittal

AU - Dewart, Paul

AU - Carman, William F

AU - Templeton, Kate

AU - Denison, Fiona C

AU - Mackenzie, D Graham

PY - 2011

Y1 - 2011

N2 - We set out to identify the level of previous exposure to influenza A (H1N1) in unvaccinated healthcare workers (HCWs) at the peak of the pandemic outbreak in the UK, with control samples collected prior to the outbreak.METHODS:Cross-sectional study (seroprevalence assessed before and at pandemic peak, with questionnaire data collected at peak of outbreak) in HCWs in Scotland.RESULTS:The prevalence of seropositivity in 493 HCWs at pandemic peak was 10.3%, which was higher than the prepandemic level by 3.7 percentage points (95% CI 0.3% to 7.3%, P = 0.048). Seropositivity rates for frontline and nonfrontline HCWs were similar.CONCLUSION:At pandemic peak, only 10.3% of HCWs were seropositive for influenza A (H1N1), so the great majority were still susceptible to infection at the introduction of the vaccination programme. Few studies have reported on seroprevalence in unvaccinated and asymptomatic participants, so our findings may have relevance to the wider population.

AB - We set out to identify the level of previous exposure to influenza A (H1N1) in unvaccinated healthcare workers (HCWs) at the peak of the pandemic outbreak in the UK, with control samples collected prior to the outbreak.METHODS:Cross-sectional study (seroprevalence assessed before and at pandemic peak, with questionnaire data collected at peak of outbreak) in HCWs in Scotland.RESULTS:The prevalence of seropositivity in 493 HCWs at pandemic peak was 10.3%, which was higher than the prepandemic level by 3.7 percentage points (95% CI 0.3% to 7.3%, P = 0.048). Seropositivity rates for frontline and nonfrontline HCWs were similar.CONCLUSION:At pandemic peak, only 10.3% of HCWs were seropositive for influenza A (H1N1), so the great majority were still susceptible to infection at the introduction of the vaccination programme. Few studies have reported on seroprevalence in unvaccinated and asymptomatic participants, so our findings may have relevance to the wider population.

KW - Adolescent

KW - Adult

KW - Aged

KW - Antibodies, Viral

KW - Cross-Sectional Studies

KW - Health Personnel

KW - Humans

KW - Influenza A Virus, H1N1 Subtype

KW - Influenza, Human

KW - Logistic regression

KW - Middle Aged

KW - pandemic

KW - PREVALENCE

KW - SCOTLAND

KW - Seroepidemiologic Studies

KW - VACCINATION

KW - Young Adult

UR - http://www.scopus.com/inward/record.url?scp=84855264201&partnerID=8YFLogxK

U2 - 10.1155/2011/407505

DO - 10.1155/2011/407505

M3 - Article

C2 - 21977047

SN - 1687-9805

VL - 2011

JO - Journal of Environmental and Public Health

JF - Journal of Environmental and Public Health

M1 - 407505

ER -

Prevalence of influenza A (H1N1) seropositivity in unvaccinated healthcare workers in Scotland at the height of the global pandemic

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

Other files and links

Fingerprint

Cite this