Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen

G R Simpson, T F Schulz, D Whitby, P M Cook, C Boshoff, L Rainbow, M R Howard, S J Gao, R A Bohenzky, P Simmonds, C Lee, A de Ruiter, A Hatzakis, R S Tedder, I V Weller, R A Weiss, P S Moore

Research output: Contribution to journalArticlepeer-review

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8, may be the infectious cause of KS. Its prevalence in the general population, on the basis of detection of the virus genome, is controversial. To investigate the seroprevalence, we measured antibodies to a recombinant capsid-related (lytic cycle) KSHV antigen and a latent antigen complex.
Original languageEnglish
Pages (from-to)1133-8
Number of pages6
JournalThe Lancet
Volume348
Issue number9035
DOIs
Publication statusPublished - 26 Oct 1996

Keywords

  • Adult
  • Antibodies, Viral
  • Antigens, Viral
  • Capsid
  • Child
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Fluorescent Antibody Technique
  • Herpesvirus 8, Human
  • Homosexuality, Male
  • Humans
  • Male
  • Open Reading Frames
  • Polymerase Chain Reaction
  • Prevalence
  • Sarcoma, Kaposi

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