Prevalence of neurological problems in a community-based sample of paediatric coeliac disease: a cross-sectional study

Thom O'Neill; Peter M Gillett; Philippa Wood; David Beattie; Deepa J Patil; Richard F Chin

doi:10.1136/archdischild-2021-321770

Prevalence of neurological problems in a community-based sample of paediatric coeliac disease: a cross-sectional study

Thom O'Neill, Peter M Gillett, Philippa Wood, David Beattie, Deepa J Patil, Richard F Chin

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: The prevalence of and risk factors for neurological problems in childhood coeliac disease (CD) are unclear.

METHODS: We performed a cross-sectional, community-based audit of CD in children diagnosed from January 2010 to December 2016 in Lothian.

RESULTS: 79 (28%) of 284 children with CD (201, 70.8% female) (mean age 8.3 years, range of 1-16) had neurological problems. Fifteen (5.3%) had headaches/migraine, 10 (3.5%) anxiety, 8 (2.8%) motor/co-ordination problems / ataxia (there were no patients with ataxia), 7 (2.5%) had behavioural issues, 5 (1.8 %) with ASD, 5 (1.8%) low mood, 4 (1.4%) ADD/ ADHD, 3 (1.1%) seizures and 2 (0.7%) had neuropathy. Neurological problems were more common with later age at CD diagnosis (OR 1.07, 95% CI 1.01 to 1.14) and male gender (OR 1.69, 95% CI 0.96 to 2.95).

CONCLUSION: Prevalence of neurological problems in children with CD in Lothian is lower than published adult CD studies and similar or lower to the reported prevalence in the general childhood population.

Original language	English
Journal	Archives of Disease in Childhood
Early online date	28 Sep 2021
DOIs	https://doi.org/10.1136/archdischild-2021-321770
Publication status	E-pub ahead of print - 28 Sep 2021

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@article{da0e1d89c15a4bdfa898986a066dae68,

title = "Prevalence of neurological problems in a community-based sample of paediatric coeliac disease: a cross-sectional study",

abstract = "BACKGROUND: The prevalence of and risk factors for neurological problems in childhood coeliac disease (CD) are unclear.METHODS: We performed a cross-sectional, community-based audit of CD in children diagnosed from January 2010 to December 2016 in Lothian.RESULTS: 79 (28%) of 284 children with CD (201, 70.8% female) (mean age 8.3 years, range of 1-16) had neurological problems. Fifteen (5.3%) had headaches/migraine, 10 (3.5%) anxiety, 8 (2.8%) motor/co-ordination problems / ataxia (there were no patients with ataxia), 7 (2.5%) had behavioural issues, 5 (1.8 %) with ASD, 5 (1.8%) low mood, 4 (1.4%) ADD/ ADHD, 3 (1.1%) seizures and 2 (0.7%) had neuropathy. Neurological problems were more common with later age at CD diagnosis (OR 1.07, 95% CI 1.01 to 1.14) and male gender (OR 1.69, 95% CI 0.96 to 2.95).CONCLUSION: Prevalence of neurological problems in children with CD in Lothian is lower than published adult CD studies and similar or lower to the reported prevalence in the general childhood population.",

author = "Thom O'Neill and Gillett, {Peter M} and Philippa Wood and David Beattie and Patil, {Deepa J} and Chin, {Richard F}",

note = "{\textcopyright} Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.",

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doi = "10.1136/archdischild-2021-321770",

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T1 - Prevalence of neurological problems in a community-based sample of paediatric coeliac disease

T2 - a cross-sectional study

AU - O'Neill, Thom

AU - Gillett, Peter M

AU - Wood, Philippa

AU - Beattie, David

AU - Patil, Deepa J

AU - Chin, Richard F

PY - 2021/9/28

Y1 - 2021/9/28

N2 - BACKGROUND: The prevalence of and risk factors for neurological problems in childhood coeliac disease (CD) are unclear.METHODS: We performed a cross-sectional, community-based audit of CD in children diagnosed from January 2010 to December 2016 in Lothian.RESULTS: 79 (28%) of 284 children with CD (201, 70.8% female) (mean age 8.3 years, range of 1-16) had neurological problems. Fifteen (5.3%) had headaches/migraine, 10 (3.5%) anxiety, 8 (2.8%) motor/co-ordination problems / ataxia (there were no patients with ataxia), 7 (2.5%) had behavioural issues, 5 (1.8 %) with ASD, 5 (1.8%) low mood, 4 (1.4%) ADD/ ADHD, 3 (1.1%) seizures and 2 (0.7%) had neuropathy. Neurological problems were more common with later age at CD diagnosis (OR 1.07, 95% CI 1.01 to 1.14) and male gender (OR 1.69, 95% CI 0.96 to 2.95).CONCLUSION: Prevalence of neurological problems in children with CD in Lothian is lower than published adult CD studies and similar or lower to the reported prevalence in the general childhood population.

AB - BACKGROUND: The prevalence of and risk factors for neurological problems in childhood coeliac disease (CD) are unclear.METHODS: We performed a cross-sectional, community-based audit of CD in children diagnosed from January 2010 to December 2016 in Lothian.RESULTS: 79 (28%) of 284 children with CD (201, 70.8% female) (mean age 8.3 years, range of 1-16) had neurological problems. Fifteen (5.3%) had headaches/migraine, 10 (3.5%) anxiety, 8 (2.8%) motor/co-ordination problems / ataxia (there were no patients with ataxia), 7 (2.5%) had behavioural issues, 5 (1.8 %) with ASD, 5 (1.8%) low mood, 4 (1.4%) ADD/ ADHD, 3 (1.1%) seizures and 2 (0.7%) had neuropathy. Neurological problems were more common with later age at CD diagnosis (OR 1.07, 95% CI 1.01 to 1.14) and male gender (OR 1.69, 95% CI 0.96 to 2.95).CONCLUSION: Prevalence of neurological problems in children with CD in Lothian is lower than published adult CD studies and similar or lower to the reported prevalence in the general childhood population.

U2 - 10.1136/archdischild-2021-321770

DO - 10.1136/archdischild-2021-321770

M3 - Article

C2 - 34583921

JO - Archives of Disease in Childhood

JF - Archives of Disease in Childhood

SN - 0003-9888

ER -

Prevalence of neurological problems in a community-based sample of paediatric coeliac disease: a cross-sectional study

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