Preventing Cognitive Decline and Dementia from Cerebral Small Vessel Disease: The LACI-1 Trial. Protocol and statistical analysis plan of a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination

Gordon Blair, Jason P Appleton, Zhe Kang Law, Fergus Doubal, Katie Flaherty, Richard Dooley, Kirsten Shuler, Carla Richardson, Iona Hamilton, Yulu Shi, Michael Stringer, Julia Boyd, Michael Thrippleton, Nikola Sprigg, Philip M Bath, Joanna Wardlaw

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Pharmacology, Toxicology and Pharmaceutical Science