Primate and bovine immature oocytes and follicles as sources of fertilizable oocytes

R. Van Den Hurk; R. Abir; E. E. Telfer; M. M. Bevers

doi:10.1093/humupd/6.5.457

Primate and bovine immature oocytes and follicles as sources of fertilizable oocytes

R. Van Den Hurk, R. Abir, E. E. Telfer, M. M. Bevers

School of Biological Sciences

Research output: Contribution to journal › Review article › peer-review

Abstract / Description of output

This review discusses the mechanisms underlying ovarian follicle development and the potential of immature follicles and oocytes from non-rodent mammalian species particularly human and bovine to serve as sources of oocytes for the in-vitro production of embryos. Factors that regulate growth and differentiation of unilaminar (primordial and primary) and multilaminar (secondary) follicles and the maturation of oocytes are highlighted. We conclude that many obstacles must still be overcome before fertilizable oocytes can be obtained from human and bovine ovaries, and more research on the quality of and culture conditions for immature oocytes and follicles is required before these can be considered as a source for in-vitro production.

Original language	English
Pages (from-to)	457-474
Number of pages	18
Journal	Human Reproduction Update
Volume	6
Issue number	5
DOIs	https://doi.org/10.1093/humupd/6.5.457
Publication status	Published - 1 Sept 2000

Keywords / Materials (for Non-textual outputs)

Cryopreservation
Follicle
Maturation in vitro
Oocyte
Ovary

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10.1093/humupd/6.5.457

Cite this

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title = "Primate and bovine immature oocytes and follicles as sources of fertilizable oocytes",

abstract = "This review discusses the mechanisms underlying ovarian follicle development and the potential of immature follicles and oocytes from non-rodent mammalian species particularly human and bovine to serve as sources of oocytes for the in-vitro production of embryos. Factors that regulate growth and differentiation of unilaminar (primordial and primary) and multilaminar (secondary) follicles and the maturation of oocytes are highlighted. We conclude that many obstacles must still be overcome before fertilizable oocytes can be obtained from human and bovine ovaries, and more research on the quality of and culture conditions for immature oocytes and follicles is required before these can be considered as a source for in-vitro production.",

keywords = "Cryopreservation, Follicle, Maturation in vitro, Oocyte, Ovary",

author = "{Van Den Hurk}, R. and R. Abir and Telfer, {E. E.} and Bevers, {M. M.}",

note = "R.Abir's work was partially sponsored by the Israel Cancer Association. The authors are grateful to Ms G.Ganzach from Rabin Medical Center in Israel for the English editing.",

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doi = "10.1093/humupd/6.5.457",

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T1 - Primate and bovine immature oocytes and follicles as sources of fertilizable oocytes

AU - Van Den Hurk, R.

AU - Abir, R.

AU - Telfer, E. E.

AU - Bevers, M. M.

N1 - R.Abir's work was partially sponsored by the Israel Cancer Association. The authors are grateful to Ms G.Ganzach from Rabin Medical Center in Israel for the English editing.

PY - 2000/9/1

Y1 - 2000/9/1

N2 - This review discusses the mechanisms underlying ovarian follicle development and the potential of immature follicles and oocytes from non-rodent mammalian species particularly human and bovine to serve as sources of oocytes for the in-vitro production of embryos. Factors that regulate growth and differentiation of unilaminar (primordial and primary) and multilaminar (secondary) follicles and the maturation of oocytes are highlighted. We conclude that many obstacles must still be overcome before fertilizable oocytes can be obtained from human and bovine ovaries, and more research on the quality of and culture conditions for immature oocytes and follicles is required before these can be considered as a source for in-vitro production.

AB - This review discusses the mechanisms underlying ovarian follicle development and the potential of immature follicles and oocytes from non-rodent mammalian species particularly human and bovine to serve as sources of oocytes for the in-vitro production of embryos. Factors that regulate growth and differentiation of unilaminar (primordial and primary) and multilaminar (secondary) follicles and the maturation of oocytes are highlighted. We conclude that many obstacles must still be overcome before fertilizable oocytes can be obtained from human and bovine ovaries, and more research on the quality of and culture conditions for immature oocytes and follicles is required before these can be considered as a source for in-vitro production.

KW - Cryopreservation

KW - Follicle

KW - Maturation in vitro

KW - Oocyte

KW - Ovary

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DO - 10.1093/humupd/6.5.457

M3 - Review article

C2 - 11045877

AN - SCOPUS:0033815539

SN - 1355-4786

VL - 6

SP - 457

EP - 474

JO - Human Reproduction Update

JF - Human Reproduction Update

IS - 5

ER -

Primate and bovine immature oocytes and follicles as sources of fertilizable oocytes

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Keywords / Materials (for Non-textual outputs)

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