Abstract / Description of output
At proestrous, the sensitivity of gonadotrophs
to gonadotrophin-releasing hormone (GnRH) increases
with repeated exposure to GnRH, a process known as selfpriming. An apparently similar phenomenon can also occur
in peptidergic neurons; activity-dependent oxytocin release
from dendrites can be potentiated by oxytocin itself. In the
brain, such priming actions have the potential to alter the
strength of communication between neuronal populations
for a very prolonged period. In the case of both oxytocin
neurons and gonadotrophs, priming appears to involve an
augmentation of a readily releasable pool of vesicles.
Original language | English |
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Pages (from-to) | 668-677 |
Number of pages | 10 |
Journal | Neurochemical Research |
Volume | 33 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 2008 |
Keywords / Materials (for Non-textual outputs)
- Hypothalamus
- Pituitary gland
- Dendritic release