Priming in Oxytocin Cells and in Gonadotrophs

Research output: Contribution to journalLiterature reviewpeer-review

Abstract / Description of output

At proestrous, the sensitivity of gonadotrophs to gonadotrophin-releasing hormone (GnRH) increases with repeated exposure to GnRH, a process known as selfpriming. An apparently similar phenomenon can also occur in peptidergic neurons; activity-dependent oxytocin release from dendrites can be potentiated by oxytocin itself. In the brain, such priming actions have the potential to alter the strength of communication between neuronal populations for a very prolonged period. In the case of both oxytocin neurons and gonadotrophs, priming appears to involve an augmentation of a readily releasable pool of vesicles.
Original languageEnglish
Pages (from-to)668-677
Number of pages10
JournalNeurochemical Research
Issue number4
Publication statusPublished - Apr 2008

Keywords / Materials (for Non-textual outputs)

  • Hypothalamus
  • Pituitary gland
  • Dendritic release


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