Prion Protein Gene Polymorphisms in Turkish Native Goat Breeds

Hasan Meydan; Erkan Pehlivan; Mustafa Muhip Özkan; Mehmet Ali Yildiz; Wilfred Goldmann

doi:10.1007/s12041-017-0763-1

Prion Protein Gene Polymorphisms in Turkish Native Goat Breeds

Hasan Meydan, Erkan Pehlivan, Mustafa Muhip Özkan, Mehmet Ali Yildiz, Wilfred Goldmann

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Susceptibility to scrapie in goats is influenced by polymorphisms of the prion protein (PRNP) gene. The aim of this study was to identify PRNP gene polymorphisms in a total of 356 scrapie disease-free goats from ten Turkish native breeds. Eighteen single nucleotide polymorphisms were detected in the caprine PRNP open reading frame. Ten previously described amino acid substitutions (I142M, H143R, N146S N146D, R151H, R154H, P168Q, R211Q, Q222K and P240S) and two novel dimorphisms, G134E and Q163P, were identified. The strongest association between caprine PRNP and relative resistance to scrapie disease has been reported previously for polymorphisms at codons 146 (S/D) and 222 (K). In the present study, these three PrP variants were relatively rare with 6.3%. This is the first report on PRNP gene variation in Turkish native goat breeds and our knowledge of these polymorphisms will assist goat breeding programs to reduce the risk of scrapie.

Original language	English
Pages (from-to)	299-305
Journal	Journal of Genetics
Volume	96
Issue number	2
Early online date	9 May 2017
DOIs	https://doi.org/10.1007/s12041-017-0763-1
Publication status	Published - Jun 2017

Keywords / Materials (for Non-textual outputs)

Scrapie
PRNP
polymorphism
Turkish native goat breeds

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10.1007/s12041-017-0763-1

art%3A10.1007%2Fs12041-017-0763-1Final published version, 539 KB

http://www.ias.ac.in/public/Resources/General/jgen/jgen-16-522-ue.pdf

Livestock neurobiology
Gill, A., Barron, R., Beard, P., Brunton, P., Goldmann, W., Hume, D., Hunter, N., Lawrence, A., Mabbott, N., Manson, J., McColl, B., Meddle, S. & Wishart, T.
BBSRC
1/04/12 → 31/03/17
Project: Research

Cite this

@article{06f0bfdb58414072984b4ecf6c4b147b,

title = "Prion Protein Gene Polymorphisms in Turkish Native Goat Breeds",

abstract = "Susceptibility to scrapie in goats is influenced by polymorphisms of the prion protein (PRNP) gene. The aim of this study was to identify PRNP gene polymorphisms in a total of 356 scrapie disease-free goats from ten Turkish native breeds. Eighteen single nucleotide polymorphisms were detected in the caprine PRNP open reading frame. Ten previously described amino acid substitutions (I142M, H143R, N146S N146D, R151H, R154H, P168Q, R211Q, Q222K and P240S) and two novel dimorphisms, G134E and Q163P, were identified. The strongest association between caprine PRNP and relative resistance to scrapie disease has been reported previously for polymorphisms at codons 146 (S/D) and 222 (K). In the present study, these three PrP variants were relatively rare with 6.3%. This is the first report on PRNP gene variation in Turkish native goat breeds and our knowledge of these polymorphisms will assist goat breeding programs to reduce the risk of scrapie.",

keywords = "Scrapie, PRNP, polymorphism, Turkish native goat breeds",

author = "Hasan Meydan and Erkan Pehlivan and {\"O}zkan, {Mustafa Muhip} and Yildiz, {Mehmet Ali} and Wilfred Goldmann",

year = "2017",

month = jun,

doi = "10.1007/s12041-017-0763-1",

language = "English",

volume = "96",

pages = "299--305",

journal = "Journal of Genetics",

issn = "0022-1333",

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TY - JOUR

T1 - Prion Protein Gene Polymorphisms in Turkish Native Goat Breeds

AU - Meydan, Hasan

AU - Pehlivan, Erkan

AU - Özkan, Mustafa Muhip

AU - Yildiz, Mehmet Ali

AU - Goldmann, Wilfred

PY - 2017/6

Y1 - 2017/6

N2 - Susceptibility to scrapie in goats is influenced by polymorphisms of the prion protein (PRNP) gene. The aim of this study was to identify PRNP gene polymorphisms in a total of 356 scrapie disease-free goats from ten Turkish native breeds. Eighteen single nucleotide polymorphisms were detected in the caprine PRNP open reading frame. Ten previously described amino acid substitutions (I142M, H143R, N146S N146D, R151H, R154H, P168Q, R211Q, Q222K and P240S) and two novel dimorphisms, G134E and Q163P, were identified. The strongest association between caprine PRNP and relative resistance to scrapie disease has been reported previously for polymorphisms at codons 146 (S/D) and 222 (K). In the present study, these three PrP variants were relatively rare with 6.3%. This is the first report on PRNP gene variation in Turkish native goat breeds and our knowledge of these polymorphisms will assist goat breeding programs to reduce the risk of scrapie.

AB - Susceptibility to scrapie in goats is influenced by polymorphisms of the prion protein (PRNP) gene. The aim of this study was to identify PRNP gene polymorphisms in a total of 356 scrapie disease-free goats from ten Turkish native breeds. Eighteen single nucleotide polymorphisms were detected in the caprine PRNP open reading frame. Ten previously described amino acid substitutions (I142M, H143R, N146S N146D, R151H, R154H, P168Q, R211Q, Q222K and P240S) and two novel dimorphisms, G134E and Q163P, were identified. The strongest association between caprine PRNP and relative resistance to scrapie disease has been reported previously for polymorphisms at codons 146 (S/D) and 222 (K). In the present study, these three PrP variants were relatively rare with 6.3%. This is the first report on PRNP gene variation in Turkish native goat breeds and our knowledge of these polymorphisms will assist goat breeding programs to reduce the risk of scrapie.

KW - Scrapie

KW - PRNP

KW - polymorphism

KW - Turkish native goat breeds

U2 - 10.1007/s12041-017-0763-1

DO - 10.1007/s12041-017-0763-1

M3 - Article

SN - 0022-1333

VL - 96

SP - 299

EP - 305

JO - Journal of Genetics

JF - Journal of Genetics

IS - 2

ER -

Prion Protein Gene Polymorphisms in Turkish Native Goat Breeds

Abstract

Keywords / Materials (for Non-textual outputs)

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Projects

Livestock neurobiology

Cite this