Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo

Shira Landskroner-Eiger; Binzhi Qian; Eric S Muise; Andrea R Nawrocki; Joel P Berger; Eugene J Fine; Wade Koba; Yingfeng Deng; Jeffrey W Pollard; Philipp E Scherer

doi:10.1158/1078-0432.CCR-08-2649

Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo

Shira Landskroner-Eiger, Binzhi Qian, Eric S Muise, Andrea R Nawrocki, Joel P Berger, Eugene J Fine, Wade Koba, Yingfeng Deng, Jeffrey W Pollard, Philipp E Scherer

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Adipocytes represent one of the most abundant constituents of the mammary gland. They are essential for mammary tumor growth and survival. Metabolically, one of the more important fat-derived factors ("adipokines") is adiponectin (APN). Serum concentrations of APN negatively correlate with body mass index and insulin resistance. To explore the association of APN with breast cancer and tumor angiogenesis, we took an in vivo approach aiming to study its role in the mouse mammary tumor virus (MMTV)-polyoma middle T antigen (PyMT) mammary tumor model.

Original language	English
Pages (from-to)	3265-76
Number of pages	12
Journal	Clinical Cancer Research
Volume	15
Issue number	10
DOIs	https://doi.org/10.1158/1078-0432.CCR-08-2649
Publication status	Published - 15 May 2009

Keywords / Materials (for Non-textual outputs)

Adiponectin
Animals
Antigens, Viral, Tumor
Apoptosis
Blotting, Western
Female
Flow Cytometry
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Glucose
Male
Mammary Neoplasms, Experimental
Mammary Tumor Virus, Mouse
Mice
Mice, Inbred C57BL
Mice, Knockout
Neovascularization, Pathologic
PPAR gamma
Polyomavirus
Positron-Emission Tomography
Reverse Transcriptase Polymerase Chain Reaction
Thiazolidinediones
Time Factors
Tumor Burden
Vascular Endothelial Growth Factor A

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10.1158/1078-0432.CCR-08-2649

Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo
Published in final edited form as: Clin Cancer Res. 2009 May 15; 15(10): 3265–3276. Published online 2009 May 15. doi: 10.1158/1078-0432.CCR-08-2649
Accepted author manuscript, 2.22 MB

http://clincancerres.aacrjournals.org/content/15/10/3265

Cite this

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title = "Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo",

abstract = "Adipocytes represent one of the most abundant constituents of the mammary gland. They are essential for mammary tumor growth and survival. Metabolically, one of the more important fat-derived factors ({"}adipokines{"}) is adiponectin (APN). Serum concentrations of APN negatively correlate with body mass index and insulin resistance. To explore the association of APN with breast cancer and tumor angiogenesis, we took an in vivo approach aiming to study its role in the mouse mammary tumor virus (MMTV)-polyoma middle T antigen (PyMT) mammary tumor model.",

keywords = "Adiponectin, Animals, Antigens, Viral, Tumor, Apoptosis, Blotting, Western, Female, Flow Cytometry, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Glucose, Male, Mammary Neoplasms, Experimental, Mammary Tumor Virus, Mouse, Mice, Mice, Inbred C57BL, Mice, Knockout, Neovascularization, Pathologic, PPAR gamma, Polyomavirus, Positron-Emission Tomography, Reverse Transcriptase Polymerase Chain Reaction, Thiazolidinediones, Time Factors, Tumor Burden, Vascular Endothelial Growth Factor A",

author = "Shira Landskroner-Eiger and Binzhi Qian and Muise, {Eric S} and Nawrocki, {Andrea R} and Berger, {Joel P} and Fine, {Eugene J} and Wade Koba and Yingfeng Deng and Pollard, {Jeffrey W} and Scherer, {Philipp E}",

year = "2009",

month = may,

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doi = "10.1158/1078-0432.CCR-08-2649",

language = "English",

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publisher = "American Association for Cancer Research Inc.",

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T1 - Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo

AU - Landskroner-Eiger, Shira

AU - Qian, Binzhi

AU - Muise, Eric S

AU - Nawrocki, Andrea R

AU - Berger, Joel P

AU - Fine, Eugene J

AU - Koba, Wade

AU - Deng, Yingfeng

AU - Pollard, Jeffrey W

AU - Scherer, Philipp E

PY - 2009/5/15

Y1 - 2009/5/15

N2 - Adipocytes represent one of the most abundant constituents of the mammary gland. They are essential for mammary tumor growth and survival. Metabolically, one of the more important fat-derived factors ("adipokines") is adiponectin (APN). Serum concentrations of APN negatively correlate with body mass index and insulin resistance. To explore the association of APN with breast cancer and tumor angiogenesis, we took an in vivo approach aiming to study its role in the mouse mammary tumor virus (MMTV)-polyoma middle T antigen (PyMT) mammary tumor model.

AB - Adipocytes represent one of the most abundant constituents of the mammary gland. They are essential for mammary tumor growth and survival. Metabolically, one of the more important fat-derived factors ("adipokines") is adiponectin (APN). Serum concentrations of APN negatively correlate with body mass index and insulin resistance. To explore the association of APN with breast cancer and tumor angiogenesis, we took an in vivo approach aiming to study its role in the mouse mammary tumor virus (MMTV)-polyoma middle T antigen (PyMT) mammary tumor model.

KW - Adiponectin

KW - Animals

KW - Antigens, Viral, Tumor

KW - Apoptosis

KW - Blotting, Western

KW - Female

KW - Flow Cytometry

KW - Gene Expression Profiling

KW - Gene Expression Regulation, Neoplastic

KW - Glucose

KW - Male

KW - Mammary Neoplasms, Experimental

KW - Mammary Tumor Virus, Mouse

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Neovascularization, Pathologic

KW - PPAR gamma

KW - Polyomavirus

KW - Positron-Emission Tomography

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Thiazolidinediones

KW - Time Factors

KW - Tumor Burden

KW - Vascular Endothelial Growth Factor A

U2 - 10.1158/1078-0432.CCR-08-2649

DO - 10.1158/1078-0432.CCR-08-2649

M3 - Article

C2 - 19447867

SN - 1078-0432

VL - 15

SP - 3265

EP - 3276

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 10

ER -

Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo

Abstract

Keywords / Materials (for Non-textual outputs)

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