Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo

Shira Landskroner-Eiger, Binzhi Qian, Eric S Muise, Andrea R Nawrocki, Joel P Berger, Eugene J Fine, Wade Koba, Yingfeng Deng, Jeffrey W Pollard, Philipp E Scherer

Research output: Contribution to journalArticlepeer-review

Abstract

Adipocytes represent one of the most abundant constituents of the mammary gland. They are essential for mammary tumor growth and survival. Metabolically, one of the more important fat-derived factors ("adipokines") is adiponectin (APN). Serum concentrations of APN negatively correlate with body mass index and insulin resistance. To explore the association of APN with breast cancer and tumor angiogenesis, we took an in vivo approach aiming to study its role in the mouse mammary tumor virus (MMTV)-polyoma middle T antigen (PyMT) mammary tumor model.
Original languageEnglish
Pages (from-to)3265-76
Number of pages12
JournalClinical Cancer Research
Volume15
Issue number10
DOIs
Publication statusPublished - 15 May 2009

Keywords

  • Adiponectin
  • Animals
  • Antigens, Viral, Tumor
  • Apoptosis
  • Blotting, Western
  • Female
  • Flow Cytometry
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Glucose
  • Male
  • Mammary Neoplasms, Experimental
  • Mammary Tumor Virus, Mouse
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Neovascularization, Pathologic
  • PPAR gamma
  • Polyomavirus
  • Positron-Emission Tomography
  • Reverse Transcriptase Polymerase Chain Reaction
  • Thiazolidinediones
  • Time Factors
  • Tumor Burden
  • Vascular Endothelial Growth Factor A

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