Probabilistic Inference of Short-Term Synaptic Plasticity in Neocortical Microcircuits

Rui P. Costa, P. Jesper Sjöström, Mark C. W. van Rossum

Research output: Contribution to journalArticlepeer-review

Abstract

Short-term synaptic plasticity is highly diverse across brain area, cortical layer, cell type, and developmental stage. Since short-term plasticity shapes neural dynamics, this diversity suggests a specific and essential role in neural information processing. Therefore, a correct characterization of short-term synaptic plasticity is an important step towards understanding and modeling neural systems. Phenomenological models have been developed, but they are usually fitted to experimental data using least-mean-square methods. We demonstrate that, for typical synaptic dynamics, such fitting may give unreliable results. As a solution, we introduce a Bayesian formulation, which yields the posterior distribution over the model parameters given the data. First, we show that common short-term plasticity protocols yield broad distributions over some model parameters. Using our result we propose a experimental protocol to more accurately determine synaptic dynamics parameters. Next, we infer the model parameters using experimental data from three different neocortical excitatory connection types. This reveals connection-specific distributions, which we use to classify synaptic dynamics. Our approach to demarcate connection-specific synaptic dynamics is an important improvement on the state of the art and reveals novel features from existing data.
Original languageEnglish
JournalFrontiers in Computational Neuroscience
Volume7
Issue number75
DOIs
Publication statusPublished - 2013

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