Probing biomolecular interactions using surface enhanced Raman spectroscopy: label-free protein detection using a G-quadruplex DNA aptamer

Michael A. Ochsenkuehn, Colin J. Campbell

Research output: Contribution to journalArticlepeer-review

Abstract

We demonstrate a strategy for label-free protein detection through monitoring the Surface Enhanced Raman Spectrum of an aptamer probe attached to a gold nanoshell. Low limit of detection and minimal non-specific binding show potential for in vitro and in vivo assays.

Original languageEnglish
Pages (from-to)2799-2801
Number of pages3
JournalChemical Communications
Volume46
Issue number16
DOIs
Publication statusPublished - 2010

Keywords

  • SCATTERING
  • SERS
  • NANOPARTICLES
  • URACIL
  • GOLD

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