Probing the substrate specificity of the catalytically self-sufficient cytochrome P450 RhF from a Rhodococcus sp

Ayhan Celik; Gareth A Roberts; John H White; Stephen K Chapman; Nicholas J Turner; Sabine L Flitsch

doi:10.1039/b609427a

Probing the substrate specificity of the catalytically self-sufficient cytochrome P450 RhF from a Rhodococcus sp

Ayhan Celik, Gareth A Roberts, John H White, Stephen K Chapman, Nicholas J Turner, Sabine L Flitsch

Research output: Contribution to journal › Article › peer-review

Abstract

Analysis of the substrate specificity of the self-sufficient cytochrome P450 RhF revealed that the enzyme tends to catalyse the dealkylation of substituted alkyl-aryl ethers with shorter alkyl moieties more readily than equivalent compounds with longer alkyl groups.

Original language	English
Pages (from-to)	4492-4
Number of pages	3
Journal	Chemical Communications
Issue number	43
DOIs	https://doi.org/10.1039/b609427a
Publication status	Published - 14 Sept 2006

Keywords / Materials (for Non-textual outputs)

Alkylation
Catalysis
Cytochrome P-450 Enzyme System/metabolism
Ethers/metabolism
Rhodococcus
Substrate Specificity

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10.1039/b609427a

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title = "Probing the substrate specificity of the catalytically self-sufficient cytochrome P450 RhF from a Rhodococcus sp",

abstract = "Analysis of the substrate specificity of the self-sufficient cytochrome P450 RhF revealed that the enzyme tends to catalyse the dealkylation of substituted alkyl-aryl ethers with shorter alkyl moieties more readily than equivalent compounds with longer alkyl groups.",

keywords = "Alkylation, Catalysis, Cytochrome P-450 Enzyme System/metabolism, Ethers/metabolism, Rhodococcus, Substrate Specificity",

author = "Ayhan Celik and Roberts, {Gareth A} and White, {John H} and Chapman, {Stephen K} and Turner, {Nicholas J} and Flitsch, {Sabine L}",

year = "2006",

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day = "14",

doi = "10.1039/b609427a",

language = "English",

pages = "4492--4",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T1 - Probing the substrate specificity of the catalytically self-sufficient cytochrome P450 RhF from a Rhodococcus sp

AU - Celik, Ayhan

AU - Roberts, Gareth A

AU - White, John H

AU - Chapman, Stephen K

AU - Turner, Nicholas J

AU - Flitsch, Sabine L

PY - 2006/9/14

Y1 - 2006/9/14

N2 - Analysis of the substrate specificity of the self-sufficient cytochrome P450 RhF revealed that the enzyme tends to catalyse the dealkylation of substituted alkyl-aryl ethers with shorter alkyl moieties more readily than equivalent compounds with longer alkyl groups.

AB - Analysis of the substrate specificity of the self-sufficient cytochrome P450 RhF revealed that the enzyme tends to catalyse the dealkylation of substituted alkyl-aryl ethers with shorter alkyl moieties more readily than equivalent compounds with longer alkyl groups.

KW - Alkylation

KW - Catalysis

KW - Cytochrome P-450 Enzyme System/metabolism

KW - Ethers/metabolism

KW - Rhodococcus

KW - Substrate Specificity

U2 - 10.1039/b609427a

DO - 10.1039/b609427a

M3 - Article

C2 - 17283795

SN - 1359-7345

SP - 4492

EP - 4494

JO - Chemical Communications

JF - Chemical Communications

IS - 43

ER -

Probing the substrate specificity of the catalytically self-sufficient cytochrome P450 RhF from a Rhodococcus sp

Abstract

Keywords / Materials (for Non-textual outputs)

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