Procalcitonin is not a reliable biomarker of bacterial co-infection in people with COVID-19 undergoing microbiological investigation at the time of hospital admission

Katharine A Relph, Clark D Russell*, Cameron Fairfield, Lance Turtle, Thushan I. De Silva, Matthew K Siggins, Thomas Drake, Ryan S Thwaites, Simon Abrams, Shona C Moore, Hayley E Hardwick, Wilna Oosthuyzen, Ewen M Harrison, Annemarie B Docherty, Peter Jm Openshaw, J Kenneth Baillie, Malcolm G Semple, Antonia Ho

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Admission procalcitonin measurements and microbiology results were available for 1040 hospitalised adults with COVID-19 (from 48,902 included in the ISARIC/WHO CCP-UK study). Although procalcitonin was higher in bacterial co-infection, this was neither clinically significant (0.33 ng/mL [IQR 0.11-1.70] vs. 0.24 [0.10-0.90]) nor diagnostically useful (ROC AUC 0.56, 95% CI 0.51-0.60).
Original languageEnglish
Article numberofac179
JournalOpen forum infectious diseases
Volume9
Issue number5
Early online date1 May 2022
DOIs
Publication statusPublished - 2 May 2022

Keywords / Materials (for Non-textual outputs)

  • COVID-19
  • SARS-CoV-2
  • procalcitonin
  • coinfection

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