Continuous Pharmaceutical Manufacturing (CPM) has received significant research interest as a way to achieve a step-change in the performance of pharmaceutical production, where innovations are incremental at best due to the current paradigm – batch production – being a relatively mature technology. In this work, a Continuous Oscillatory Baffled Crystalliser (COBC) for paracetamol crystallisation has been modelled and optimal design and operation has been determined via nonlinear optimization (NLP). Clear trends emerge, with rate of antisolvent use having a marked impact of COBC volumes; crystal seed mass loading also has a strong effect. However, there are tradeoffs between mass efficiency, cost and volume, and product crystal size. The trends and optima illustrate how process modelling, simulation and optimisation provide clear insights into process performance and decisions on acceptable tradeoffs.
|Title of host publication
|28th European Symposium on Computer Aided Process Engineering
|Anton Friedl, Jiri Klemeš, Stefan Radl, Petar Varbanov, Thomas Wallek
|Place of Publication
|Number of pages
|Published - 11 Jun 2018
|Computer-Aided Chemical Engineering