Projects per year
Abstract / Description of output
Part B of the Trail Making Test (TMT-B) is widely used as a quick and easy to administer measure of executive dysfunction. The current study investigated the relationships between TMT-B performance, brain volumes, cortical thickness and white matter water diffusion characteristics in a large sample of older participants, before and after controlling for processing speed. Four hundred and eleven healthy, community-dwelling older adults who were all born in 1936 were assessed on TMT-B, 5 tests of processing speed, and provided contemporaneous structural and diffusion MRI data. Significant relationships were found between slower TMT-B completion times and thinner cortex in the frontal, temporal and inferior parietal regions as well as the Sylvian fissure/insula. Slower TMT-B completion time was also significantly associated with poorer white matter microstructure of the left anterior thalamic radiation, and the right uncinate fasciculus. The majority of these associations were markedly attenuated when additionally controlling for processing speed. These data suggest that individual differences in processing speed contribute to the associations between TMT-B completion time and the grey and white matter structure of older adults.
Original language | English |
---|---|
Pages (from-to) | 92-103 |
Journal | Cortex |
Volume | 95 |
Early online date | 1 Aug 2017 |
DOIs | |
Publication status | Published - Oct 2017 |
Keywords / Materials (for Non-textual outputs)
- aging
- executive function
- neuroimaging
- processing speed
- Trail Making Test
Fingerprint
Dive into the research topics of 'Processing speed and the relationship between Trail Making Test-B performance, cortical thinning and white matter microstructure in older adults'. Together they form a unique fingerprint.Projects
- 3 Finished
-
Brain imaging and cognitive ageing in the Lothian Birth Cohort 1936: III
Wardlaw, J., Bastin, M. & Deary, I.
1/05/15 → 30/04/19
Project: Research
-
-
Brain White mater imaging and cognitive ageing in the Lothian Birth Cohort of 1936:II
Deary, I., Bastin, M., Penke, L., Starr, J. & Wardlaw, J.
8/06/11 → 7/03/15
Project: Research
Profiles
-
Sarah E MacPherson
- School of Philosophy, Psychology and Language Sciences - Personal Chair of Cognitive Neuropsychology
- Edinburgh Neuroscience
Person: Academic: Research Active