Profiles of cognitive impairment in the continuum from normal cognition to Alzheimer's Clinical Syndrome: Contributions of the Short-term Memory Binding tests

Mario Cecchini, Maria Paula Foss, Vb Tumas, Flávia Patrocínio, RDC Correia, N. Novaretti, TR Brozinga, V.S. Bahia, LC de Souza, Henrique Cerqueira Guimarães, Paulo Caramelli, Thaís Bento Lima-silva, Luciana Cassimiro, Sônia Maria Dozzi Brucki, Ricardo Nitrini, Sergio Della Sala, Mario Parra, Mônica Sanches Yassuda

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Short-term memory binding (STMB) tests assess conjunctive binding, in which participants should remember the integration of features, such as shapes (or objects) and colors, forming a unique representation in memory. In this study, we investigated two STMB paradigms: Change Detection (CD) and Free Recall (FR). OBJECTIVE: To investigate the cognitive profile in the CD and FR tasks of three diagnostic groups: cognitively unimpaired (CU), mild cognitive impairment (MCI) and Alzheimer's Clinical Syndrome (ACS). In addition, we aimed to calculate and compare the accuracy of the CD and FR tasks to identify MCI and ACS. METHODS: Participants were 24 CU, 24 MCI and 37 ACS. The cognitive scores of the clinical groups were compared using ANOVA and ROC analyses were carried out to verify the accuracy of the STMB tasks. RESULTS: In the CD task, CU was different from MCI and ACS (CU > MCI = ACS), while in the FR task all groups were different (CU > MCI > ACS). The ROC analyses showed an AUC of 0.855 comparing CU with MCI for the CD task and 0.975 for the FR. The AUC comparing CU and ACS was 0.924 for the CD and 0.973 for the FR task. The FR task showed better accuracy to identify MCI patients, and the same accuracy to detect ACS. CONCLUSION: The present findings indicate that impairments in CD and FR of bound representations are features of the cognitive profiles of MCI and ACS patients.
Original languageEnglish
Pages (from-to)1331-1340
JournalInternational Journal of Geriatric Psychiatry
Volume35
Issue number11
Early online date24 Jul 2020
DOIs
Publication statusPublished - 13 Oct 2020

Keywords

  • Mild Cognitive Impairment
  • cognitive aging
  • Alzheimer’s Disease
  • Alzheimer's Clinical Syndrome
  • short-term memory
  • memory binding
  • working memory

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