TY - JOUR
T1 - Profiles of cognitive impairment in the continuum from normal cognition to Alzheimer's Clinical Syndrome
T2 - Contributions of the Short-term Memory Binding tests
AU - Cecchini, Mario
AU - Foss, Maria Paula
AU - Tumas, Vb
AU - Patrocínio, Flávia
AU - Correia, RDC
AU - Novaretti, N.
AU - Brozinga, TR
AU - Bahia, V.S.
AU - de Souza, LC
AU - Guimarães, Henrique Cerqueira
AU - Caramelli, Paulo
AU - Lima-silva, Thaís Bento
AU - Cassimiro, Luciana
AU - Brucki, Sônia Maria Dozzi
AU - Nitrini, Ricardo
AU - Della Sala, Sergio
AU - Parra, Mario
AU - Yassuda, Mônica Sanches
PY - 2020/10/13
Y1 - 2020/10/13
N2 - BACKGROUND: Short-term memory binding (STMB) tests assess conjunctive binding, in which participants should remember the integration of features, such as shapes (or objects) and colors, forming a unique representation in memory. In this study, we investigated two STMB paradigms: Change Detection (CD) and Free Recall (FR). OBJECTIVE: To investigate the cognitive profile in the CD and FR tasks of three diagnostic groups: cognitively unimpaired (CU), mild cognitive impairment (MCI) and Alzheimer's Clinical Syndrome (ACS). In addition, we aimed to calculate and compare the accuracy of the CD and FR tasks to identify MCI and ACS. METHODS: Participants were 24 CU, 24 MCI and 37 ACS. The cognitive scores of the clinical groups were compared using ANOVA and ROC analyses were carried out to verify the accuracy of the STMB tasks. RESULTS: In the CD task, CU was different from MCI and ACS (CU > MCI = ACS), while in the FR task all groups were different (CU > MCI > ACS). The ROC analyses showed an AUC of 0.855 comparing CU with MCI for the CD task and 0.975 for the FR. The AUC comparing CU and ACS was 0.924 for the CD and 0.973 for the FR task. The FR task showed better accuracy to identify MCI patients, and the same accuracy to detect ACS. CONCLUSION: The present findings indicate that impairments in CD and FR of bound representations are features of the cognitive profiles of MCI and ACS patients.
AB - BACKGROUND: Short-term memory binding (STMB) tests assess conjunctive binding, in which participants should remember the integration of features, such as shapes (or objects) and colors, forming a unique representation in memory. In this study, we investigated two STMB paradigms: Change Detection (CD) and Free Recall (FR). OBJECTIVE: To investigate the cognitive profile in the CD and FR tasks of three diagnostic groups: cognitively unimpaired (CU), mild cognitive impairment (MCI) and Alzheimer's Clinical Syndrome (ACS). In addition, we aimed to calculate and compare the accuracy of the CD and FR tasks to identify MCI and ACS. METHODS: Participants were 24 CU, 24 MCI and 37 ACS. The cognitive scores of the clinical groups were compared using ANOVA and ROC analyses were carried out to verify the accuracy of the STMB tasks. RESULTS: In the CD task, CU was different from MCI and ACS (CU > MCI = ACS), while in the FR task all groups were different (CU > MCI > ACS). The ROC analyses showed an AUC of 0.855 comparing CU with MCI for the CD task and 0.975 for the FR. The AUC comparing CU and ACS was 0.924 for the CD and 0.973 for the FR task. The FR task showed better accuracy to identify MCI patients, and the same accuracy to detect ACS. CONCLUSION: The present findings indicate that impairments in CD and FR of bound representations are features of the cognitive profiles of MCI and ACS patients.
KW - Mild Cognitive Impairment
KW - cognitive aging
KW - Alzheimer’s Disease
KW - Alzheimer's Clinical Syndrome
KW - short-term memory
KW - memory binding
KW - working memory
U2 - 10.1002/gps.5370
DO - 10.1002/gps.5370
M3 - Article
SN - 0885-6230
VL - 35
SP - 1331
EP - 1340
JO - International Journal of Geriatric Psychiatry
JF - International Journal of Geriatric Psychiatry
IS - 11
ER -