Profound diarrhoea and weight loss in an immunocompromised patient

George Ashton, Alan Shand, Ian Arnott, Shahida Din

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

A 75-year-old man was admitted with a 3-month history of worsening diarrhoea and weight loss. He was on long-term immunosuppression following cardiac transplantation. Investigations revealed herpes simplex oesophagitis and stool samples were positive for norovirus. Treatment with acyclovir and nitazoxanide resulted in a complete resolution of symptoms. Norovirus is a common cause of infectious gastroenteritis, but immunosuppressed patients may present with chronic diarrhoea rather than an acute illness. This case highlights the importance of a low clinical threshold for testing for norovirus infection in immunocompromised patients.

Original languageEnglish
Article numbere236913
JournalBMJ Case Reports
Issue number1
Publication statusPublished - 18 Jan 2021

Keywords / Materials (for Non-textual outputs)

  • Aged
  • Caliciviridae Infections/complications
  • Chronic Disease
  • Diarrhea/immunology
  • Gastroenteritis/complications
  • Heart Transplantation
  • Humans
  • Immunocompromised Host
  • Male
  • Norovirus/isolation & purification
  • Postoperative Complications/diagnosis
  • Weight Loss/immunology


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