Prognostic role of tumour-associated macrophages and macrophage scavenger receptor 1 in prostate cancer: a systematic review and meta-analysis

Jian Cao, Jun Liu, Ran Xu, Xuan Zhu, Xiaokun Zhao, Bin-Zhi Qian

Research output: Contribution to journalArticlepeer-review

Abstract

Recent studies suggested that the tumour associated macrophages may be associated with prostate cancer outcome. A meta-analysis was performed to evaluate the prognostic value of tumor associated macrophages and macrophage scavenger receptor 1, marker for a subset of macrophages, by pooled hazard ratio and 95% confidence intervals from qualified studies following a systemic search. The results indicate that higher infiltration of tumor associated macrophages predicts poor overall survival (HR=1.57, 95%CI: 1.15-1.98), but not biochemical recurrence (HR=1.01, 95%CI: 0.98-1.04) or recurrence-free survival (HR=1.03, 95%CI: 0.05-2.01). In contrast, elevated level of macrophage scavenger receptor 1 was significantly associated with better recurrence-free survival (HR=3.26, 95%CI: 1.22-5.29). Thus, our analysis confirmed the prognostic value of these markers in prostate cancer outcome. We also discussed potential causes of the controversies in the literature and future research directions.
Original languageEnglish
Pages (from-to)83261-83269
JournalOncotarget
Volume8
Issue number47
DOIs
Publication statusPublished - 27 Jun 2017

Keywords

  • Prostate Cancer
  • Tumor-associated Macrophages
  • Macrophage Scavenger Receptor 1
  • Prognosis
  • Meta-analysis

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