Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke: a systematic review and meta-analysis

Alejandro Bustamante, Tomas Sobrino, Dolors Giralt, Teresa Garcia-Berrocoso, Victor Llombart, Iratxe Ugarriza, Marc Espadaler, Noelia Rodriguez, Catherine Sudlow, Mar Castellanos, Craig J. Smith, Manuel Rodriguez-Yanez, Ulrike Waje-Andreassen, David Tanne, Jun Oto, Mark Barber, Hans Worthmann, Katja E. Wartenberg, Kyra J. Becker, Baidarbhi ChakrabortySeung-Hun Oh, William N. Whiteley, Jose Castillo, Joan Montaner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We aimed to quantify the association of blood interleukin-6 (IL-6) concentrations with poor outcome after stroke and its added predictive value over clinical information. Meta-analysis of 24 studies confirmed this association with a weighted mean difference of 3.443 (1.592-5.294) pg/mL, despite high heterogeneity and publication bias. Individual participant data including 4112 stroke patients showed standardized IL-6 levels in the 4th quartile were independently associated with poor outcome (OR=2.346 (1.814-3.033), p<0.0001). However, the additional predictive value of IL-6 was moderate (IDI=1.5%, NRI=5.35%). Overall these results indicate an unlikely translation of IL-6 into clinical practice for this purpose.

Original languageEnglish
Pages (from-to)215-224
Number of pages10
JournalJournal of Neuroimmunology
Volume274
Issue number1-2
DOIs
Publication statusPublished - 15 Sep 2014

Keywords

  • Stroke
  • Interleukin-6
  • Outcome
  • Meta-analysis
  • Post-stroke infection
  • Individual participant data analysis
  • ACUTE ISCHEMIC-STROKE
  • NECROSIS-FACTOR-ALPHA
  • ACUTE BRAIN ISCHEMIA
  • LACUNAR INFARCTIONS
  • BIOMARKERS
  • INFLAMMATION
  • MORTALITY
  • MARKERS
  • DAMAGE
  • THROMBOLYSIS

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