Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke: a systematic review and meta-analysis

Alejandro Bustamante; Tomas Sobrino; Dolors Giralt; Teresa Garcia-Berrocoso; Victor Llombart; Iratxe Ugarriza; Marc Espadaler; Noelia Rodriguez; Catherine Sudlow; Mar Castellanos; Craig J. Smith; Manuel Rodriguez-Yanez; Ulrike Waje-Andreassen; David Tanne; Jun Oto; Mark Barber; Hans Worthmann; Katja E. Wartenberg; Kyra J. Becker; Baidarbhi Chakraborty; Seung-Hun Oh; William N. Whiteley; Jose Castillo; Joan Montaner

doi:10.1016/j.jneuroim.2014.07.015

Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke: a systematic review and meta-analysis

Alejandro Bustamante
, Tomas Sobrino
, Dolors Giralt
, Teresa Garcia-Berrocoso
, Victor Llombart
, Iratxe Ugarriza
, Marc Espadaler
, Noelia Rodriguez
, Catherine Sudlow
, Mar Castellanos
, Craig J. Smith
, Manuel Rodriguez-Yanez
, Ulrike Waje-Andreassen
, David Tanne
, Jun Oto
, Mark Barber
, Hans Worthmann
, Katja E. Wartenberg
, Kyra J. Becker
, Baidarbhi Chakraborty

Seung-Hun Oh, William N. Whiteley, Jose Castillo, Joan Montaner^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

We aimed to quantify the association of blood interleukin-6 (IL-6) concentrations with poor outcome after stroke and its added predictive value over clinical information. Meta-analysis of 24 studies confirmed this association with a weighted mean difference of 3.443 (1.592-5.294) pg/mL, despite high heterogeneity and publication bias. Individual participant data including 4112 stroke patients showed standardized IL-6 levels in the 4th quartile were independently associated with poor outcome (OR=2.346 (1.814-3.033), p<0.0001). However, the additional predictive value of IL-6 was moderate (IDI=1.5%, NRI=5.35%). Overall these results indicate an unlikely translation of IL-6 into clinical practice for this purpose.

Original language	English
Pages (from-to)	215-224
Number of pages	10
Journal	Journal of Neuroimmunology
Volume	274
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2014.07.015
Publication status	Published - 15 Sept 2014

Keywords / Materials (for Non-textual outputs)

Stroke
Interleukin-6
Outcome
Meta-analysis
Post-stroke infection
Individual participant data analysis
ACUTE ISCHEMIC-STROKE
NECROSIS-FACTOR-ALPHA
ACUTE BRAIN ISCHEMIA
LACUNAR INFARCTIONS
BIOMARKERS
INFLAMMATION
MORTALITY
MARKERS
DAMAGE
THROMBOLYSIS

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10.1016/j.jneuroim.2014.07.015

Targeted treatment for acute stroke: development of prognostic models & decision support tools
Whiteley, W. (Principal Investigator) & Sandercock, P. (Co-investigator)
MRC
1/09/10 → 28/02/16
Project: Research

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Bustamante, A., Sobrino, T., Giralt, D., Garcia-Berrocoso, T., Llombart, V., Ugarriza, I., Espadaler, M., Rodriguez, N., Sudlow, C., Castellanos, M., Smith, C. J., Rodriguez-Yanez, M., Waje-Andreassen, U., Tanne, D., Oto, J., Barber, M., Worthmann, H., Wartenberg, K. E., Becker, K. J., ... Montaner, J. (2014). Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke: a systematic review and meta-analysis. Journal of Neuroimmunology, 274(1-2), 215-224. https://doi.org/10.1016/j.jneuroim.2014.07.015

@article{53bdc6c63a514290b195c279ce984a30,

title = "Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke: a systematic review and meta-analysis",

abstract = "We aimed to quantify the association of blood interleukin-6 (IL-6) concentrations with poor outcome after stroke and its added predictive value over clinical information. Meta-analysis of 24 studies confirmed this association with a weighted mean difference of 3.443 (1.592-5.294) pg/mL, despite high heterogeneity and publication bias. Individual participant data including 4112 stroke patients showed standardized IL-6 levels in the 4th quartile were independently associated with poor outcome (OR=2.346 (1.814-3.033), p<0.0001). However, the additional predictive value of IL-6 was moderate (IDI=1.5\%, NRI=5.35\%). Overall these results indicate an unlikely translation of IL-6 into clinical practice for this purpose.",

keywords = "Stroke, Interleukin-6, Outcome, Meta-analysis, Post-stroke infection, Individual participant data analysis, ACUTE ISCHEMIC-STROKE, NECROSIS-FACTOR-ALPHA, ACUTE BRAIN ISCHEMIA, LACUNAR INFARCTIONS, BIOMARKERS, INFLAMMATION, MORTALITY, MARKERS, DAMAGE, THROMBOLYSIS",

author = "Alejandro Bustamante and Tomas Sobrino and Dolors Giralt and Teresa Garcia-Berrocoso and Victor Llombart and Iratxe Ugarriza and Marc Espadaler and Noelia Rodriguez and Catherine Sudlow and Mar Castellanos and Smith, \{Craig J.\} and Manuel Rodriguez-Yanez and Ulrike Waje-Andreassen and David Tanne and Jun Oto and Mark Barber and Hans Worthmann and Wartenberg, \{Katja E.\} and Becker, \{Kyra J.\} and Baidarbhi Chakraborty and Seung-Hun Oh and Whiteley, \{William N.\} and Jose Castillo and Joan Montaner",

year = "2014",

month = sep,

day = "15",

doi = "10.1016/j.jneuroim.2014.07.015",

language = "English",

volume = "274",

pages = "215--224",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

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number = "1-2",

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Bustamante, A, Sobrino, T, Giralt, D, Garcia-Berrocoso, T, Llombart, V, Ugarriza, I, Espadaler, M, Rodriguez, N, Sudlow, C, Castellanos, M, Smith, CJ, Rodriguez-Yanez, M, Waje-Andreassen, U, Tanne, D, Oto, J, Barber, M, Worthmann, H, Wartenberg, KE, Becker, KJ, Chakraborty, B, Oh, S-H, Whiteley, WN, Castillo, J & Montaner, J 2014, 'Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke: a systematic review and meta-analysis', Journal of Neuroimmunology, vol. 274, no. 1-2, pp. 215-224. https://doi.org/10.1016/j.jneuroim.2014.07.015

TY - JOUR

T1 - Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke

T2 - a systematic review and meta-analysis

AU - Bustamante, Alejandro

AU - Sobrino, Tomas

AU - Giralt, Dolors

AU - Garcia-Berrocoso, Teresa

AU - Llombart, Victor

AU - Ugarriza, Iratxe

AU - Espadaler, Marc

AU - Rodriguez, Noelia

AU - Sudlow, Catherine

AU - Castellanos, Mar

AU - Smith, Craig J.

AU - Rodriguez-Yanez, Manuel

AU - Waje-Andreassen, Ulrike

AU - Tanne, David

AU - Oto, Jun

AU - Barber, Mark

AU - Worthmann, Hans

AU - Wartenberg, Katja E.

AU - Becker, Kyra J.

AU - Chakraborty, Baidarbhi

AU - Oh, Seung-Hun

AU - Whiteley, William N.

AU - Castillo, Jose

AU - Montaner, Joan

PY - 2014/9/15

Y1 - 2014/9/15

N2 - We aimed to quantify the association of blood interleukin-6 (IL-6) concentrations with poor outcome after stroke and its added predictive value over clinical information. Meta-analysis of 24 studies confirmed this association with a weighted mean difference of 3.443 (1.592-5.294) pg/mL, despite high heterogeneity and publication bias. Individual participant data including 4112 stroke patients showed standardized IL-6 levels in the 4th quartile were independently associated with poor outcome (OR=2.346 (1.814-3.033), p<0.0001). However, the additional predictive value of IL-6 was moderate (IDI=1.5%, NRI=5.35%). Overall these results indicate an unlikely translation of IL-6 into clinical practice for this purpose.

AB - We aimed to quantify the association of blood interleukin-6 (IL-6) concentrations with poor outcome after stroke and its added predictive value over clinical information. Meta-analysis of 24 studies confirmed this association with a weighted mean difference of 3.443 (1.592-5.294) pg/mL, despite high heterogeneity and publication bias. Individual participant data including 4112 stroke patients showed standardized IL-6 levels in the 4th quartile were independently associated with poor outcome (OR=2.346 (1.814-3.033), p<0.0001). However, the additional predictive value of IL-6 was moderate (IDI=1.5%, NRI=5.35%). Overall these results indicate an unlikely translation of IL-6 into clinical practice for this purpose.

KW - Stroke

KW - Interleukin-6

KW - Outcome

KW - Meta-analysis

KW - Post-stroke infection

KW - Individual participant data analysis

KW - ACUTE ISCHEMIC-STROKE

KW - NECROSIS-FACTOR-ALPHA

KW - ACUTE BRAIN ISCHEMIA

KW - LACUNAR INFARCTIONS

KW - BIOMARKERS

KW - INFLAMMATION

KW - MORTALITY

KW - MARKERS

KW - DAMAGE

KW - THROMBOLYSIS

U2 - 10.1016/j.jneuroim.2014.07.015

DO - 10.1016/j.jneuroim.2014.07.015

M3 - Article

C2 - 25091431

SN - 0165-5728

VL - 274

SP - 215

EP - 224

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke: a systematic review and meta-analysis

Abstract

Keywords / Materials (for Non-textual outputs)

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Projects

Targeted treatment for acute stroke: development of prognostic models & decision support tools

Cite this