Programming living sensors for environment, health and biomanufacturing

Xinyi Wan, Behide Saltepe, Luyang Yu, Baojun Wang

Research output: Contribution to journalArticlepeer-review

Abstract

Synthetic biology offers new tools and capabilities of engineering cells with desired functions for example as new biosensing platforms leveraging engineered microbes. In the last two decades, bacterial cells have been programmed to sense and respond to various input cues for versatile purposes including environmental monitoring, disease diagnosis and adaptive biomanufacturing. Despite demonstrated proof-of-concept success in the lab, the real-world applications of microbial sensors have been restricted due to certain technical and societal limitations. Yet, most limitations can be addressed by new technological developments in synthetic biology such as circuit design, biocontainment and machine learning. Here, we summarize the latest advances in synthetic biology and discuss how they could accelerate the development, enhance the performance and address the present limitations of microbial sensors to facilitate their use in the field. We view that programmable living sensors are promising sensing platforms to achieve sustainable, affordable, and easy-to-use on-site detection in diverse settings.
Original languageEnglish
Number of pages9
JournalMicrobial biotechnology
Early online date7 May 2021
DOIs
Publication statusE-pub ahead of print - 7 May 2021

Keywords

  • living sensors
  • synthetic biology
  • environment
  • health
  • biomanufacturing

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