Progress and prospects in rat genetics: a community view

Tim Aitman, John K. Critser, Edwin Cuppen, Anna Dominiczak, Xose M. Fernandez-Suarez, Jonathan Flint, Dominique Gauguier, Aron M. Geurts, Michael Gould, Peter C. Harris, Rikard Holmdahl, Norbert Hubner, Zsuzsanna Izsvak, Howard J. Jacob, Takashi Kuramoto, Anne E. Kwitek, Anna Marrone, Tomoji Mashimo, Carol Moreno, John MullinsLinda Mullins, Tomas Olsson, Michal Pravenec, Lela Riley, Kathrin Saar, Tadao Serikawa, James D. Shull, Claude Szpirer, Simon N. Twigger, Birger Voigt, Kim Worley

Research output: Contribution to journalArticlepeer-review

Abstract

The rat is an important system for modeling human disease. Four years ago, the rich 150-year history of rat research was transformed by the sequencing of the rat genome, ushering in an era of exceptional opportunity for identifying genes and pathways underlying disease phenotypes. Genome-wide association studies in human populations have recently provided a direct approach for finding robust genetic associations in common diseases, but identifying the precise genes and their mechanisms of action remains problematic. In the context of significant progress in rat genomic resources over the past decade, we outline achievements in rat gene discovery to date, show how these findings have been translated to human disease, and document an increasing pace of discovery of new disease genes, pathways and mechanisms. Finally, we present a set of principles that justify continuing and strengthening genetic studies in the rat model, and further development of genomic infrastructure for rat research.

Original languageEnglish
Pages (from-to)516-522
Number of pages7
JournalNature Genetics
Volume40
Issue number5
DOIs
Publication statusPublished - May 2008

Cite this