Proinflammatory Cytokine Induction of 11Beta-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) in Human Adipocytes Is Mediated by MEK, C/EBPβ, and NF-κB/RelA

Cristina L Esteves, Val Kelly, Amandine Breton, Ashley I Taylor, Christopher C West, Francesc X Donadeu, Bruno Péault, Jonathan R Seckl, Karen E Chapman

Research output: Contribution to journalArticlepeer-review

Abstract

Context:Levels of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which regenerates active glucocorticoids, are selectively elevated in adipose tissue in human obesity and metabolic syndrome, both conditions associated with chronic low-grade inflammation. 11β-HSD1 expression is induced by proinflammatory cytokines in a variety of cell types, including in human adipocytes differentiated in vitro.Objective:Our objective was to determine the mechanisms by which proinflammatory cytokines induce 11β-HSD1 in human adipocytes.Results:The proinflammatory cytokines IL-1α (10 ng/mL) and TNFα (20 ng/mL) increased 11β-HSD1 mRNA levels in human primary adipocyte fractions and Simpson-Golabi-Behmel syndrome (SGBS) adipocytes (P
Original languageEnglish
Pages (from-to)E160-E168
JournalJournal of Clinical Endocrinology & Metabolism
Volume99
Issue number1
Early online date15 Nov 2013
DOIs
Publication statusPublished - 2014

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