Abstract
Objective: To assess the occurrence of acute kidney injury (AKI) in dogs undergoing cardiac surgery under cardiopulmonary bypass (CPB) and explore associations between traditional and novel serum and urinary biomarkers. Design: Prospective cohort study conducted between July 2018 and April 2019. Setting: University teaching hospital. Animals: Nineteen dogs undergoing cardiac surgery under CPB with preoperative serum creatinine <140 μmol/L (<1.6 mg/dl). Interventions: Blood and urine samples were obtained at 4 time points: preoperatively following general anesthesia induction, immediately postoperatively, and 2 and 4 days postoperatively (T 1, T 2, T 3, and T 4). AKI was defined as an increase in serum creatinine ≥26.4 μmol/L (≥0.3 mg/dl) above baseline within 48 hours. Serum creatinine, C-reactive protein (CRP), symmetric dimethylarginine (SDMA), inosine, beta-aminoisobutyric acid (BAIB), urinary clusterin (uClus), and urinary cystatin B (uCysB) were measured. Data were log-transformed (log 10) when appropriate and assessed using linear mixed-effects models. Measurements and Main Results: AKI occurred in 3 of 19 dogs (15.8%, 95% confidence interval: 0.047–0.384). Inosine increased at T 2 (adjusted mean ± standard error: 53 ± 5.6) in all dogs, and then gradually decreased. Log 10uCysB increased at T 2 (2.3 ± 0.1) in all dogs and remained high. Log 10CRP and log 10uClus increased significantly at T 3 (1.9 ± 0.1 and 3.6 ± 0.1, respectively) in all dogs and remained increased. There was a significant positive association between serum creatinine and SDMA (P < 0.001, estimate ± standard error: 0.06 ± 0.00), between log 10CRP and log 10uClus (P < 0.001, 0.35 ± 0.08), between SDMA and creatinine as well as between SDMA and BAIB (P < 0.001, 11.1 ± 0.83 and P < 0.001, 1.06 ± 0.22, respectively) for all dogs at all time points. Conclusions: Inosine and uCysB concentrations changed in all dogs immediately following a surgery under CPB and may indicate tubular injury. Further studies are required to ascertain the usefulness of those biomarkers in early detection of AKI.
Original language | English |
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Pages (from-to) | 733-742 |
Journal | Journal of Veterinary Emergency and Critical Care |
Volume | 32 |
Issue number | 6 |
Early online date | 20 Sept 2022 |
DOIs | |
Publication status | E-pub ahead of print - 20 Sept 2022 |
Keywords / Materials (for Non-textual outputs)
- AKI
- BAIB
- CPB
- CRP
- SDMA
- clusterin
- creatinine
- cystatin B
- inosine