Prospective multi-centre Voxel Based Morphometry study employing scanner specific segmentations: procedure development using CaliBrain structural MRI data

T William J Moorhead, Viktoria-Eleni Gountouna, Dominic E Job, Andrew M McIntosh, Liana Romaniuk, G Katherine S Lymer, Heather C Whalley, Gordon D Waiter, David Brennan, Trevor S Ahearn, Jonathan Cavanagh, Barrie Condon, J Douglas Steele, Joanna M Wardlaw, Stephen M Lawrie

Research output: Contribution to journalArticlepeer-review

Abstract

Structural Magnetic Resonance Imaging (sMRI) of the brain is employed in the assessment of a wide range of neuropsychiatric disorders. In order to improve statistical power in such studies it is desirable to pool scanning resources from multiple centres. The CaliBrain project was designed to provide for an assessment of scanner differences at three centres in Scotland, and to assess the practicality of pooling scans from multiple-centres.
Original languageEnglish
Pages (from-to)8
JournalBMC medical imaging
Volume9
DOIs
Publication statusPublished - 2009

Keywords

  • Adult
  • Brain
  • Calibration
  • Female
  • Great Britain
  • Humans
  • Image Enhancement
  • Image Interpretation, Computer-Assisted
  • Imaging, Three-Dimensional
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Prospective Studies
  • Quality Assurance, Health Care
  • Reference Values
  • Reproducibility of Results
  • Sensitivity and Specificity

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