Prospective study design and data analysis in UK Biobank

Naomi E Allen, Ben Lacey, Deborah A Lawlor, J. P. Pell, John Gallacher, Liam Smeeth, Paul Elliott, Paul M Matthews, Ronan A Lyons, Anthony D Whetton, Anneke Lucassen, Matthew E Hurles, Michael Chapman, Andrew W Roddam, Natalie K Fitzpatrick, Anna L Hansell, Rebecca Hardy, Riccardo E Marioni, Valerie B O'Donnell, Julie WilliamsCecilia M Lindgren, Mark Effingham, Jonathan Sellors, John Danesh, Rory Collins

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

Population-based prospective studies, such as UK Biobank, are valuable for generating and testing hypotheses about the potential causes of human disease. We describe how UK Biobank's study design, data access policies, and approaches to statistical analysis can help to minimize error and improve the interpretability of research findings, with implications for other population-based prospective studies being established worldwide.

Original languageEnglish
Pages (from-to)eadf4428
JournalScience Translational Medicine
Volume16
Issue number729
DOIs
Publication statusPublished - 10 Jan 2024

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