Projects per year
Prion diseases are subacute neurodegenerative diseases that affect humans and animals. An abnormally folded isoform (PrP(Sc)) of the host cellular prion protein is considered to constitute the major, if not sole, component of the infectious prion. The occurrence of variant Creutzfeldt-Jakob disease in humans most likely arose due to consumption of food contaminated with bovine spongiform encephalopathy prions. The demonstration that some prion infections may have the capacity to transmit to other species, especially humans, has focused attention on the development of safe and effective vaccines against these invariably fatal and currently incurable diseases. Although much effort has been invested in the development of safe and effective anti-PrP vaccines, many important issues remain to be resolved.
|Number of pages||4|
|Journal||Expert Review of Vaccines|
|Early online date||30 Sep 2014|
|Publication status||Published - Sep 2015|
- prion disease
- transmissible spongiform encephalopathy
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- 4 Finished
Determining the role of m cells in tse agent neuroinvasion from the intestine
Mabbott, N. & Mahajan, A.
1/11/12 → 31/03/16
The infuence of galt in tse agent in neuroinvasion from the large intestine
5/05/09 → 31/10/12
Determining the role of cxcr5-expressing dendritic cells in imune function and tse agent neuroinvasion from the intestine
1/05/09 → 30/09/12