Protein fold irregularities that hinder sequence analysis

R B Russell, C P Ponting

Research output: Contribution to journalArticlepeer-review


The detection of homologous protein sequences frequently provides useful predictions of function and structure. Methods for homology searching have continued to improve, such that very distant evolutionary relationships can now be detected. Little attention has been paid, however, to the problems of detecting homology when domains are inserted or permuted. Here we review recent occurrences of these phenomena and discuss methods that permit their detection.

Original languageEnglish
Pages (from-to)364-71
Number of pages8
JournalCurrent opinion in structural biology
Issue number3
Publication statusPublished - Jun 1998


  • Amino Acid Sequence
  • Animals
  • Evolution, Molecular
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Protein Folding
  • Protein Structure, Secondary
  • Proteins
  • Sequence Alignment
  • Sequence Homology, Amino Acid


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