Protein folding in Escherichia coli: the chaperonin GroE and its substrates

Millicent Masters, Garry Blakely, Andrew Coulson, Neil McLennan, Vollodymyr Yerko, John Acord

Research output: Contribution to journalArticlepeer-review


A brief summary of the role of DnaK and GroE chaperones in protein folding precedes a discussion of the role of GroE in Escherichia coli. We consider its obligate substrates, the 8 that are both obligate and essential, and the prospects for constructing a mutant that could survive without it. Structural features of GroE-dependent polypeptides are also considered.
Original languageEnglish
Pages (from-to)267-77
Number of pages11
JournalResearch in microbiology
Issue number4
Publication statusPublished - 2009


  • Chaperones
  • GroE
  • DnaK
  • Protein folding

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