Abstract
Cross-linking in combination with mass spectrometry can be used as a tool for structural modeling of protein complexes and multidomain proteins. Although cross-links represent only weak structural constraints, the combination of a limited set of experimental cross-links with molecular docking/modeling is often sufficient to determine the structure of a protein complex or multidomain protein at low resolution.
Original language | English |
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Pages (from-to) | 459-74 |
Number of pages | 16 |
Journal | Methods in Molecular Biology |
Volume | 426 |
DOIs | |
Publication status | Published - 2008 |