Protein structure determination using a combination of cross-linking, mass spectrometry, and molecular modeling

Dmitri Mouradov, Gordon King, Ian L Ross, Jade K Forwood, David A Hume, Andrea Sinz, Jennifer L Martin, Bostjan Kobe, Thomas Huber

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Cross-linking in combination with mass spectrometry can be used as a tool for structural modeling of protein complexes and multidomain proteins. Although cross-links represent only weak structural constraints, the combination of a limited set of experimental cross-links with molecular docking/modeling is often sufficient to determine the structure of a protein complex or multidomain protein at low resolution.
Original languageEnglish
Pages (from-to)459-74
Number of pages16
JournalMethods in Molecular Biology
Volume426
DOIs
Publication statusPublished - 2008

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