Protein synthesis is severely diminished following a simulated upper GI bleed in patients with cirrhosis

Steven W M Olde Damink, Rajiv Jalan, Nicolaas E P Deutz, Peter C Hayes, Peter B Soeters

Research output: Contribution to journalArticlepeer-review

Abstract

An upper gastrointestinal (GI) bleed in cirrhotic patients has been hypothesised to induce catabolism due to the absence of the essential branched chain amino acid (BCAA) isoleucine and an abundance of the BCAA leucine in haemoglobin. We tested whether an upper GI bleed produces hypoisoleucinemia via BCAA antagonism and impairs protein synthesis.
Original languageEnglish
Pages (from-to)726-31
Number of pages6
JournalJournal of Hepatology
Volume49
Issue number5
DOIs
Publication statusPublished - 2008

Keywords

  • Adult
  • Amino Acids, Branched-Chain
  • Female
  • Gastrointestinal Hemorrhage
  • Humans
  • Isoleucine
  • Liver Cirrhosis
  • Liver Cirrhosis, Alcoholic
  • Male
  • Middle Aged
  • Models, Biological
  • Oxidation-Reduction
  • Protein Biosynthesis

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