Protein synthesis is severely diminished following a simulated upper GI bleed in patients with cirrhosis

Steven W M Olde Damink; Rajiv Jalan; Nicolaas E P Deutz; Peter C Hayes; Peter B Soeters

doi:10.1016/j.jhep.2008.04.018

Protein synthesis is severely diminished following a simulated upper GI bleed in patients with cirrhosis

Steven W M Olde Damink, Rajiv Jalan, Nicolaas E P Deutz, Peter C Hayes, Peter B Soeters

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

An upper gastrointestinal (GI) bleed in cirrhotic patients has been hypothesised to induce catabolism due to the absence of the essential branched chain amino acid (BCAA) isoleucine and an abundance of the BCAA leucine in haemoglobin. We tested whether an upper GI bleed produces hypoisoleucinemia via BCAA antagonism and impairs protein synthesis.

Original language	English
Pages (from-to)	726-31
Number of pages	6
Journal	Journal of Hepatology
Volume	49
Issue number	5
DOIs	https://doi.org/10.1016/j.jhep.2008.04.018
Publication status	Published - 2008

Keywords / Materials (for Non-textual outputs)

Adult
Amino Acids, Branched-Chain
Female
Gastrointestinal Hemorrhage
Humans
Isoleucine
Liver Cirrhosis
Liver Cirrhosis, Alcoholic
Male
Middle Aged
Models, Biological
Oxidation-Reduction
Protein Biosynthesis

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10.1016/j.jhep.2008.04.018

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@article{ccd40384eca84b94863c396df94ad888,

title = "Protein synthesis is severely diminished following a simulated upper GI bleed in patients with cirrhosis",

abstract = "An upper gastrointestinal (GI) bleed in cirrhotic patients has been hypothesised to induce catabolism due to the absence of the essential branched chain amino acid (BCAA) isoleucine and an abundance of the BCAA leucine in haemoglobin. We tested whether an upper GI bleed produces hypoisoleucinemia via BCAA antagonism and impairs protein synthesis.",

keywords = "Adult, Amino Acids, Branched-Chain, Female, Gastrointestinal Hemorrhage, Humans, Isoleucine, Liver Cirrhosis, Liver Cirrhosis, Alcoholic, Male, Middle Aged, Models, Biological, Oxidation-Reduction, Protein Biosynthesis",

author = "{Olde Damink}, {Steven W M} and Rajiv Jalan and Deutz, {Nicolaas E P} and Hayes, {Peter C} and Soeters, {Peter B}",

year = "2008",

doi = "10.1016/j.jhep.2008.04.018",

language = "English",

volume = "49",

pages = "726--31",

journal = "Journal of Hepatology",

issn = "0168-8278",

publisher = "Elsevier",

number = "5",

}

TY - JOUR

T1 - Protein synthesis is severely diminished following a simulated upper GI bleed in patients with cirrhosis

AU - Olde Damink, Steven W M

AU - Jalan, Rajiv

AU - Deutz, Nicolaas E P

AU - Hayes, Peter C

AU - Soeters, Peter B

PY - 2008

Y1 - 2008

N2 - An upper gastrointestinal (GI) bleed in cirrhotic patients has been hypothesised to induce catabolism due to the absence of the essential branched chain amino acid (BCAA) isoleucine and an abundance of the BCAA leucine in haemoglobin. We tested whether an upper GI bleed produces hypoisoleucinemia via BCAA antagonism and impairs protein synthesis.

AB - An upper gastrointestinal (GI) bleed in cirrhotic patients has been hypothesised to induce catabolism due to the absence of the essential branched chain amino acid (BCAA) isoleucine and an abundance of the BCAA leucine in haemoglobin. We tested whether an upper GI bleed produces hypoisoleucinemia via BCAA antagonism and impairs protein synthesis.

KW - Adult

KW - Amino Acids, Branched-Chain

KW - Female

KW - Gastrointestinal Hemorrhage

KW - Humans

KW - Isoleucine

KW - Liver Cirrhosis

KW - Liver Cirrhosis, Alcoholic

KW - Male

KW - Middle Aged

KW - Models, Biological

KW - Oxidation-Reduction

KW - Protein Biosynthesis

U2 - 10.1016/j.jhep.2008.04.018

DO - 10.1016/j.jhep.2008.04.018

M3 - Article

C2 - 18602715

SN - 0168-8278

VL - 49

SP - 726

EP - 731

JO - Journal of Hepatology

JF - Journal of Hepatology

IS - 5

ER -

Protein synthesis is severely diminished following a simulated upper GI bleed in patients with cirrhosis

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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