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Abstract / Description of output
We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the submitted predictions. While the overall ability to predict three-dimensional protein structures continues to impress, reproducing uncommon features not previously observed in experimental structures is still a challenge. Furthermore, instances with conformational flexibility and large multimeric complexes highlight the need for novel scoring strategies to better emphasize biologically relevant structural regions. Looking ahead, closer integration of computational and experimental techniques will play a key role in determining the next challenges to be unraveled in the field of structural molecular biology.
Original language | English |
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Pages (from-to) | 1571-1599 |
Number of pages | 29 |
Journal | Proteins: Structure, Function, and Bioinformatics |
Volume | 91 |
Issue number | 12 |
Early online date | 26 Jul 2023 |
DOIs | |
Publication status | Published - 1 Dec 2023 |
Keywords / Materials (for Non-textual outputs)
- CASP
- cryo-EM
- protein structure prediction
- X-ray crystallography
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Dive into the research topics of 'Protein target highlights in CASP15: Analysis of models by structure providers'. Together they form a unique fingerprint.Projects
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Molecular basis of chromosome synapsis and genetic exchange in mammalian meiosis
15/02/21 → 14/02/26
Project: Research