Projects per year
Abstract / Description of output
Observing the structures of proteins within the cell and tracking structural changes under different cellular conditions are the ultimate challenges for structural biology. This, however, requires an experimental technique that can generate sufficient data for structure determination and is applicable in the native environment of proteins. Crosslinking/mass spectrometry (CLMS) and protein structure determination have recently advanced to meet these requirements and crosslinking-driven de novo structure determination in native environments is now possible. In this opinion article, we highlight recent successes in the field of CLMS with protein structure modeling and challenges it still holds.
Original language | English |
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Pages (from-to) | 157-169 |
Number of pages | 13 |
Journal | Trends in biochemical sciences |
Volume | 43 |
Issue number | 3 |
Early online date | 31 Jan 2018 |
DOIs | |
Publication status | Published - 1 Mar 2018 |
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Dive into the research topics of 'Protein Tertiary Structure by Crosslinking/Mass Spectrometry'. Together they form a unique fingerprint.Projects
- 3 Finished
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Protein structures in the context of time and space by mass spectrometry
1/06/14 → 31/05/21
Project: Research