Proteins containing the UBA domain are able to bind to multi-ubiquitin chains

C R Wilkinson, M Seeger, R Hartmann-Petersen, M Stone, M Wallace, C Semple, C Gordon

Research output: Contribution to journalArticlepeer-review

Abstract

The UBA domain is a motif found in a variety of proteins, some of which are associated with the ubiquitin-proteasome system. We describe the isolation of a fission-yeast gene, mud1+, which encodes a UBA domain containing protein that is able to bind multi-ubiquitin chains. We show that the UBA domain is responsible for this activity. Two other proteins containing this motif, the fission-yeast homologues of Rad23 and Dsk2, are also shown to bind multi-ubiquitin chains via their UBA domains. These two proteins are implicated, along with the fission-yeast Pus1(S5a/Rpn10) subunit of the 26 S proteasome, in the recognition and turnover of substrates by this proteolytic complex.
Original languageEnglish
Pages (from-to)939-43
Number of pages5
JournalNature Cell Biology
Volume3
Issue number10
DOIs
Publication statusPublished - 2001

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