Proteomic analysis of postsynaptic proteins in regions of the human neocortex

Marcia Roy, Oksana Sorokina, Nathan Skene, Clémence Simonnet, Francesca Mazzola, Ruud Zwart, Emanuele Sher, Colin Smith, J. Douglas Armstrong, Seth Grant

Research output: Contribution to journalArticlepeer-review

Abstract

The postsynaptic proteome of excitatory synapses comprises ~1,000 highly conserved proteins that control the behavioral repertoire and mutations disrupting their function cause >130 brain diseases. Here, we document the composition of postsynaptic proteomes in human neocortical regions and integrate it with genetic, functional and structural magnetic resonance imaging, positron emission tomography imaging, and behavioral data. Neocortical regions show signatures of expression of individual proteins, protein complexes, biochemical and metabolic pathways. The compositional signatures in brain regions involved with language, emotion and memory functions were characterized. Integrating large-scale GWAS with regional proteome data identifies the same cortical region for smoking behavior as found with fMRI data. The neocortical postsynaptic proteome data resource can be used to link genetics to brain imaging and behavior, and to study the role of postsynaptic proteins in localization of brain functions.
Original languageEnglish
Pages (from-to)130–138
Number of pages15
JournalNature Neuroscience
Volume21
Issue number1
Early online date4 Dec 2017
DOIs
Publication statusPublished - 1 Jan 2018

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