Protocol for meta-analysis of temperature reduction in animal models of cardiac arrest

H. Olai, G. Thornéus, H. Watson, Malcolm MacLeod, H. Friberg, J. Rhodes, N. Nielsen, T. Cronberg, T. Deierborg

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Targeted temperature management (TTM) of 32–34 °C has been the standard treatment for out-of-hospital cardiac arrest since clinical trials in 2002 showed benefits to survival and neurological outcome. Recently, this treatment has been challenged by another clinical trial showing no difference in outcome between TTM of 33 °C and 36 °C. This protocol describes the methodology for a meta-analysis detailing temperature-reducing interventions to treat global ischaemia in animal models. By combining relevant data sets in the literature, we will explore the experimental evidence for TTM. Our aims are to explain possible translational gaps and provide methodological considerations for future experimental research and clinical trials.
Original languageEnglish
Article numbere00014
JournalEvidence-based Preclinical Medicine
Volume3
Issue number1
Early online date3 May 2016
DOIs
Publication statusPublished - 1 Aug 2016

Fingerprint

Dive into the research topics of 'Protocol for meta-analysis of temperature reduction in animal models of cardiac arrest'. Together they form a unique fingerprint.

Cite this