Abstract / Description of output
Paget's disease of bone (PDB) is characterised by focal increases in bone turnover, affecting one or more bones throughout the skeleton. This disrupts normal bone architecture and causes pain, deformity, deafness, osteoarthritis, and fractures. Genetic factors are recognised to play a role in PDB and it is now possible to carry out genetic tests for research. In view of this, it is timely to investigate the clinical potential for a programme of genetic testing and preventative treatment for people who have a family history of PDB, to prevent or delay the development of PDB. Evidence from non-genetic conditions, that have effective treatments, demonstrates that patients' beliefs may affect the acceptability and uptake of treatment. Two groups of beliefs (illness and treatment representations) are likely to be influential. Illness representations describe how people see their illness, as outlined in Leventhal's Self-Regulation Model. Treatment representations describe how people perceive potential treatment for their disease. People offered a programme of genetic testing and treatment will develop their own treatment representations based on what is offered, but the beliefs rather than the objective programme of treatment are likely to determine their willingness to participate. The Theory of Planned Behaviour is a theoretical model that predicts behaviours from people's beliefs about the consequences, social pressures and perceived control over the behaviour, including uptake of treatment.
Original language | English |
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Pages (from-to) | 71 |
Journal | BMC Health Services Research |
Volume | 6 |
DOIs | |
Publication status | Published - 2006 |
Keywords / Materials (for Non-textual outputs)
- Adult
- Aged
- Attitude to Health
- Bone Resorption
- Clinical Protocols
- Cohort Studies
- Family
- Genetic Counseling
- Genetic Predisposition to Disease
- Genetic Testing
- Great Britain
- Health Behavior
- Humans
- Intergenerational Relations
- Interviews as Topic
- Male
- Middle Aged
- Models, Psychological
- Osteitis Deformans
- Patient Acceptance of Health Care
- Research Design