Protocol for stage 2 of the GaP study (genetic testing acceptability for Paget's disease of bone): a questionnaire study to investigate whether relatives of people with Paget's disease would accept genetic testing and preventive treatment if they were available

Anne L Langston, Marie Johnston, Jill Francis, Clare Robertson, Marion K Campbell, Vikki A Entwistle, Theresa Marteau, Graeme Maclennan, John Weinman, Marilyn McCallum, Zosia Miedzybrodska, Keith Charnock, Stuart H Ralston

Research output: Contribution to journalArticlepeer-review

Abstract

Paget's disease of bone (PDB) disrupts normal bone architecture and causes pain, deformity, deafness, osteoarthritis, and fractures. Genetic factors play a role in PDB and genetic tests are now conducted for research purposes. It is thus timely to investigate the potential for a clinical programme of genetic testing and preventative treatment for people who have a family history of PDB. This study examines the beliefs of relatives of people with PDB. It focuses particularly on illness and treatment representations as predictors of the acceptability and uptake of potential clinical programmes. Illness representations are examined using Leventhal's Common Sense Self-Regulation Model while cognitions about treatment behaviours (acceptance of testing and treatment uptake) are conceptualised within the Theory of Planned Behaviour.
Original languageEnglish
Pages (from-to)116
JournalBMC Health Services Research
Volume8
DOIs
Publication statusPublished - 2008

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