Proton spectroscopic imaging of brain metabolites in basal ganglia of healthy older adults

Jehill Parikh, Michael Thrippleton, Catherine Murray, Paul Armitage, BA Harris, Peter Andrews, Joanna Wardlaw, John Starr, Ian Deary, Ian Marshall

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

We sought to measure brain metabolite levels in healthy older people.
Materials and methods
Spectroscopic imaging at the level of the basal ganglia was applied in 40 participants aged 73–74 years. Levels of the metabolites N-acetyl aspartate (NAA), choline, and creatine were determined in "institutional units" (IU) corrected for T1 and T2 relaxation effects. Structural imaging enabled determination of grey matter (GM), white matter (WM), and cerebrospinal fluid content. ANOVA analysis was carried out for voxels satisfying quality criteria.
Creatine levels were greater in GM than WM (57 vs. 44 IU, p < 0.001), whereas choline and NAA levels were greater in WM than GM [13 vs. 10 IU (p < 0.001) and 76 versus 70 IU (p = 0.03), respectively]. The ratio of NAA/cre was greater in WM than GM (2.1 vs. 1.4, p = 0.001) as was that of cho/cre (0.32 vs. 0.16, p < 0.001). A low voxel yield was due to brain atrophy and the difficulties of shimming over an extended region of brain.
This study addresses the current lack of information on brain metabolite levels in older adults. The normal features of ageing result in a substantial loss of reliable voxels and should be taken into account when planning studies. Improvements in shimming are also required before the methods can be applied more widely
Original languageEnglish
Pages (from-to)251-257
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Issue number3
Early online date14 Oct 2014
Publication statusPublished - Jun 2015


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