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Moreover, the most likely polymorphism candidates for conferring BSE resistance were tested in the frame of a EU-funded BSE challenge and serial time kill study with goats. Following an oral challenge with goat passaged BSE homogenate, animals were clinically assessed after given time points. Moreover, biopsies of tonsil and rectal mucosal and necropsies were performed periodically. Goats were euthanized at defined time points and samples from the lymphoreticular, the central and peripheral nervous system and the placenta and milk were collected and examined histopathologically, immunohistochemically, by immunoblot and/or transgenic mouse bioassay. These investigations revealed that the BSE pathogenesis in goats is not as widespread as seen for example in scrapie in sheep and goats or ovine BSE. Moreover, these studies show that PRNP polymorphism Q/K 222 is strongly associated with an increased but possibly not absolute resistance to BSE under experimental conditions. Together with data from other experiments/groups these data hold promise for future breeding programs for genetically TSE-resistant goats.
|Publication status||Published - 3 Dec 2014|
|Event||3rd Iberian Congress on Prions - Faucltad de Veterinaria, Zaragoza, Spain|
Duration: 2 Dec 2014 → 3 Dec 2014
|Conference||3rd Iberian Congress on Prions|
|Period||2/12/14 → 3/12/14|
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- 3 Finished
Towards breeding of goats for genetically determined TSE resistance. A PrP gene survey of the national goat herd and the development of breeding strategies for goats in Great Britain.
1/11/12 → 31/03/16
Goat BSE I: Proposal for improvement of goat TSE discriminative diagnosis and susceptability based assessment of BSE in goat milk and meat - goat BSE
1/05/08 → 30/11/10