Pseudomonas sax Genes Overcome Aliphatic Isothiocyanate-Mediated Non-Host Resistance in Arabidopsis

Jun Fan, Casey Crooks, Gary Creissen, Lionel Hill, Shirley Fairhurst, Peter Doerner, Chris Lamb

Research output: Contribution to journalArticlepeer-review

Abstract

Most plant-microbe interactions do not result in disease; natural products restrict non-host pathogens. We found that sulforaphane (4-methylsulfinylbutyl isothiocyanate), a natural product derived from aliphatic glucosinolates, inhibits growth in Arabidopsis of non-host Pseudomonas bacteria in planta. Multiple sax genes (saxCAB/F/D/G) were identified in Pseudomonas species virulent on Arabidopsis. These sax genes are required to overwhelm isothiocyanate-based defenses and facilitate a disease outcome, especially in the young leaves critical for plant survival. Introduction of saxCAB genes into non-host strains enabled them to overcome these Arabidopsis defenses. Our study shows that aliphatic isothiocyanates, previously shown to limit damage by herbivores, are also crucial, robust, and developmentally regulated defenses that underpin non-host resistance in the Arabidopsis-Pseudomonas pathosystem.

Original languageEnglish
Pages (from-to)1185-1188
Number of pages4
JournalScience
Volume331
Issue number6021
DOIs
Publication statusPublished - 4 Mar 2011

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