Psychiatric symptoms and CAG repeats in neurologically asymptomatic Huntington's disease gene carriers

G E Berrios, A C Wagle, I S Marková, S A Wagle, L W Ho, D C Rubinsztein, J Whittaker, C Ffrench-Constant, A Kershaw, A Rosser, T Bak, J R Hodges

Research output: Contribution to journalArticlepeer-review


The putative relationship between the psychiatric profile of a sample of neurologically asymptomatic Huntington's disease gene carriers and CAG repeats was investigated. The psychiatric assessments (by consultant psychiatrist and computerised battery) were undertaken before the genetic testing was carried out. In this way, the informational distortions caused by neurological and cognitive deficits were avoided. The hypothesis that there is a relationship between psychiatric and CAG repeats was tested by seeking direct correlations between psychiatric systems and CAG repeats, and also by correcting the correlation by the number of years above or below the estimated age of onset in Huntington's disease. Scores for irritability and cognitive failures were high in the sample. There was no correlation between any psychiatric variable and CAG repeats. Possible explanations for this lack of correlations are discussed.
Original languageEnglish
Pages (from-to)217-25
Number of pages9
JournalPsychiatry Research
Issue number3
Publication statusPublished - 2001


  • Adenine
  • Adult
  • Age of Onset
  • Cognition
  • Cytosine
  • Female
  • Genetic Predisposition to Disease
  • Guanine
  • Heterozygote
  • Humans
  • Huntington Disease
  • Irritable Mood
  • Male
  • Middle Aged
  • Prospective Studies
  • Psychiatric Status Rating Scales
  • Trinucleotide Repeat Expansion


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