Pulmonary Arterial Enlargement and Acute Exacerbations of COPD

J Michael Wells, George R Washko, MeiLan K Han, Naseer Abbas, Hrudaya Nath, A James Mamary, Elizabeth Regan, William C Bailey, Fernando J Martinez, Elizabeth Westfall, Terri H Beaty, Douglas Curran-Everett, Jeffrey L Curtis, John E Hokanson, David A Lynch, Barry J Make, James D Crapo, Edwin K Silverman, Russell P Bowler, Mark T DransfieldCOPDGene Investigators, Edwin van Beek

Research output: Contribution to journalArticlepeer-review

Abstract

Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with accelerated loss of lung function and death. Identification of patients at risk for these events, particularly those requiring hospitalization, is of major importance. Severe pulmonary hypertension is an important complication of advanced COPD and predicts acute exacerbations, though pulmonary vascular abnormalities also occur early in the course of the disease. We hypothesized that a computed tomographic (CT) metric of pulmonary vascular disease (pulmonary artery enlargement, as determined by a ratio of the diameter of the pulmonary artery to the diameter of the aorta [PA:A ratio] of >1) would be associated with severe COPD exacerbations.
Original languageEnglish
Pages (from-to)913-921
Number of pages9
JournalNew England Journal of Medicine
Volume367
Issue number10
DOIs
Publication statusPublished - 6 Sep 2012

Keywords

  • Acute Disease
  • Aged
  • Aorta
  • Aortography
  • Female
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Observation
  • Pulmonary Artery
  • Pulmonary Disease, Chronic Obstructive
  • Recurrence
  • Risk Factors
  • Smoking
  • Tomography, X-Ray Computed

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