Pulmonary Arterial Enlargement and Acute Exacerbations of COPD

J Michael Wells; George R Washko; MeiLan K Han; Naseer Abbas; Hrudaya Nath; A James Mamary; Elizabeth Regan; William C Bailey; Fernando J Martinez; Elizabeth Westfall; Terri H Beaty; Douglas Curran-Everett; Jeffrey L Curtis; John E Hokanson; David A Lynch; Barry J Make; James D Crapo; Edwin K Silverman; Russell P Bowler; Mark T Dransfield; COPDGene Investigators; Edwin van Beek

doi:10.1056/NEJMoa1203830

Pulmonary Arterial Enlargement and Acute Exacerbations of COPD

J Michael Wells, George R Washko, MeiLan K Han, Naseer Abbas, Hrudaya Nath, A James Mamary, Elizabeth Regan, William C Bailey, Fernando J Martinez, Elizabeth Westfall, Terri H Beaty, Douglas Curran-Everett, Jeffrey L Curtis, John E Hokanson, David A Lynch, Barry J Make, James D Crapo, Edwin K Silverman, Russell P Bowler, Mark T DransfieldCOPDGene Investigators, Edwin van Beek (Member of Group Organisation)

Research output: Contribution to journal › Article › peer-review

Abstract

Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with accelerated loss of lung function and death. Identification of patients at risk for these events, particularly those requiring hospitalization, is of major importance. Severe pulmonary hypertension is an important complication of advanced COPD and predicts acute exacerbations, though pulmonary vascular abnormalities also occur early in the course of the disease. We hypothesized that a computed tomographic (CT) metric of pulmonary vascular disease (pulmonary artery enlargement, as determined by a ratio of the diameter of the pulmonary artery to the diameter of the aorta [PA:A ratio] of >1) would be associated with severe COPD exacerbations.

Original language	English
Pages (from-to)	913-921
Number of pages	9
Journal	New England Journal of Medicine
Volume	367
Issue number	10
DOIs	https://doi.org/10.1056/NEJMoa1203830
Publication status	Published - 6 Sept 2012

Keywords / Materials (for Non-textual outputs)

Acute Disease
Aged
Aorta
Aortography
Female
Humans
Logistic Models
Male
Middle Aged
Observation
Pulmonary Artery
Pulmonary Disease, Chronic Obstructive
Recurrence
Risk Factors
Smoking
Tomography, X-Ray Computed

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10.1056/NEJMoa1203830

Pulmonary arterial enlargement and acute exacerbations of COPD
Published in final edited form as: N Engl J Med. 2012 September 6; 367(10): 913–921. Published online 2012 September 3. doi: 10.1056/NEJMoa1203830
Accepted author manuscript, 790 KB

http://www.nejm.org/doi/full/10.1056/NEJMoa1203830

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Wells, J. M., Washko, G. R., Han, M. K., Abbas, N., Nath, H., Mamary, A. J., Regan, E., Bailey, W. C., Martinez, F. J., Westfall, E., Beaty, T. H., Curran-Everett, D., Curtis, J. L., Hokanson, J. E., Lynch, D. A., Make, B. J., Crapo, J. D., Silverman, E. K., Bowler, R. P., ... van Beek, E. (2012). Pulmonary Arterial Enlargement and Acute Exacerbations of COPD. New England Journal of Medicine, 367(10), 913-921. https://doi.org/10.1056/NEJMoa1203830

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abstract = "Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with accelerated loss of lung function and death. Identification of patients at risk for these events, particularly those requiring hospitalization, is of major importance. Severe pulmonary hypertension is an important complication of advanced COPD and predicts acute exacerbations, though pulmonary vascular abnormalities also occur early in the course of the disease. We hypothesized that a computed tomographic (CT) metric of pulmonary vascular disease (pulmonary artery enlargement, as determined by a ratio of the diameter of the pulmonary artery to the diameter of the aorta [PA:A ratio] of >1) would be associated with severe COPD exacerbations.",

keywords = "Acute Disease, Aged, Aorta, Aortography, Female, Humans, Logistic Models, Male, Middle Aged, Observation, Pulmonary Artery, Pulmonary Disease, Chronic Obstructive, Recurrence, Risk Factors, Smoking, Tomography, X-Ray Computed",

author = "Wells, {J Michael} and Washko, {George R} and Han, {MeiLan K} and Naseer Abbas and Hrudaya Nath and Mamary, {A James} and Elizabeth Regan and Bailey, {William C} and Martinez, {Fernando J} and Elizabeth Westfall and Beaty, {Terri H} and Douglas Curran-Everett and Curtis, {Jeffrey L} and Hokanson, {John E} and Lynch, {David A} and Make, {Barry J} and Crapo, {James D} and Silverman, {Edwin K} and Bowler, {Russell P} and Dransfield, {Mark T} and {COPDGene Investigators} and {van Beek}, Edwin",

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Wells, JM, Washko, GR, Han, MK, Abbas, N, Nath, H, Mamary, AJ, Regan, E, Bailey, WC, Martinez, FJ, Westfall, E, Beaty, TH, Curran-Everett, D, Curtis, JL, Hokanson, JE, Lynch, DA, Make, BJ, Crapo, JD, Silverman, EK, Bowler, RP, Dransfield, MT, COPDGene Investigators & van Beek, E 2012, 'Pulmonary Arterial Enlargement and Acute Exacerbations of COPD', New England Journal of Medicine, vol. 367, no. 10, pp. 913-921. https://doi.org/10.1056/NEJMoa1203830

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T1 - Pulmonary Arterial Enlargement and Acute Exacerbations of COPD

AU - Wells, J Michael

AU - Washko, George R

AU - Han, MeiLan K

AU - Abbas, Naseer

AU - Nath, Hrudaya

AU - Mamary, A James

AU - Regan, Elizabeth

AU - Bailey, William C

AU - Martinez, Fernando J

AU - Westfall, Elizabeth

AU - Beaty, Terri H

AU - Curran-Everett, Douglas

AU - Curtis, Jeffrey L

AU - Hokanson, John E

AU - Lynch, David A

AU - Make, Barry J

AU - Crapo, James D

AU - Silverman, Edwin K

AU - Bowler, Russell P

AU - Dransfield, Mark T

AU - COPDGene Investigators

A2 - van Beek, Edwin

PY - 2012/9/6

Y1 - 2012/9/6

N2 - Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with accelerated loss of lung function and death. Identification of patients at risk for these events, particularly those requiring hospitalization, is of major importance. Severe pulmonary hypertension is an important complication of advanced COPD and predicts acute exacerbations, though pulmonary vascular abnormalities also occur early in the course of the disease. We hypothesized that a computed tomographic (CT) metric of pulmonary vascular disease (pulmonary artery enlargement, as determined by a ratio of the diameter of the pulmonary artery to the diameter of the aorta [PA:A ratio] of >1) would be associated with severe COPD exacerbations.

AB - Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with accelerated loss of lung function and death. Identification of patients at risk for these events, particularly those requiring hospitalization, is of major importance. Severe pulmonary hypertension is an important complication of advanced COPD and predicts acute exacerbations, though pulmonary vascular abnormalities also occur early in the course of the disease. We hypothesized that a computed tomographic (CT) metric of pulmonary vascular disease (pulmonary artery enlargement, as determined by a ratio of the diameter of the pulmonary artery to the diameter of the aorta [PA:A ratio] of >1) would be associated with severe COPD exacerbations.

KW - Acute Disease

KW - Aged

KW - Aorta

KW - Aortography

KW - Female

KW - Humans

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Observation

KW - Pulmonary Artery

KW - Pulmonary Disease, Chronic Obstructive

KW - Recurrence

KW - Risk Factors

KW - Smoking

KW - Tomography, X-Ray Computed

U2 - 10.1056/NEJMoa1203830

DO - 10.1056/NEJMoa1203830

M3 - Article

C2 - 22938715

SN - 0028-4793

VL - 367

SP - 913

EP - 921

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 10

ER -

Pulmonary Arterial Enlargement and Acute Exacerbations of COPD

Abstract

Keywords / Materials (for Non-textual outputs)

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