Pulmonary macrophages and SARS-Cov2 infection

Calum C Bain; Adriano G Rossi; Christopher D Lucas

doi:10.1016/bs.ircmb.2022.01.001

Pulmonary macrophages and SARS-Cov2 infection

Calum C Bain, Adriano G Rossi, Christopher D Lucas^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Abstract / Description of output

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the largest global pandemic in living memory, with between 4.5 and 15M deaths globally from coronavirus disease 2019 (COVID-19). This has led to an unparalleled global, collaborative effort to understand the pathogenesis of this devastating disease using state-of-the-art technologies. A consistent feature of severe COVID-19 is dys- regulation of pulmonary macrophages, cells that under normal physiological conditions play vital roles in maintaining lung homeostasis and immunity. In this article, we will discuss a selection of the pivotal findings examining the role of monocytes and mac- rophages in SARS-CoV-2 infection and place this in context of recent advances made in understanding the fundamental immunobiology of these cells to try to understand how key homeostatic cells come to be a central pathogenic component of severe COVID-19 and key cells to target for therapeutic gain.

Original language	English
Title of host publication	International Review of Cell and Molecular Biology
Editors	Samanta A. Mariani, Luca Cassetta, Lorenzo Galluzzi
Place of Publication	Oxford, UK
Publisher	Academic Press
Number of pages	1
Volume	367
ISBN (Electronic)	9780323907415
DOIs	https://doi.org/10.1016/bs.ircmb.2022.01.001
Publication status	Published - 20 Apr 2022

Publication series

Name	International Review of Cell and Molecular Biology
Publisher	Elsevier Inc.

Keywords / Materials (for Non-textual outputs)

lung
macrophage
coronavirus
SARS-CoV-2

Access to Document

10.1016/bs.ircmb.2022.01.001

IRCMB_Chapter_BainRossiLucas_final - new refsAccepted author manuscript, 171 KBLicence: Creative Commons: Attribution (CC-BY)

Investigating the role of TGF¿¿ in the functional imprinting of pulmonary macrophages in health and disease
Bain, C.
UK-based charities
1/09/17 → 31/12/23
Project: Research
Macrophage-epithelial communication promotes lung repair after injury
Lucas, C.
UK-based charities
3/07/17 → 4/08/22
Project: Research

Cite this

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title = "Pulmonary macrophages and SARS-Cov2 infection",

abstract = "The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the largest global pandemic in living memory, with between 4.5 and 15M deaths globally from coronavirus disease 2019 (COVID-19). This has led to an unparalleled global, collaborative effort to understand the pathogenesis of this devastating disease using state-of-the-art technologies. A consistent feature of severe COVID-19 is dys- regulation of pulmonary macrophages, cells that under normal physiological conditions play vital roles in maintaining lung homeostasis and immunity. In this article, we will discuss a selection of the pivotal findings examining the role of monocytes and mac- rophages in SARS-CoV-2 infection and place this in context of recent advances made in understanding the fundamental immunobiology of these cells to try to understand how key homeostatic cells come to be a central pathogenic component of severe COVID-19 and key cells to target for therapeutic gain.",

keywords = "lung, macrophage, coronavirus, SARS-CoV-2",

author = "Bain, {Calum C} and Rossi, {Adriano G} and Lucas, {Christopher D}",

note = "Funding Information: C.D.L. is funded by a Wellcome Trust Clinical Career Development Fellowship (206566/Z/17/Z). C.C.B. is funded by a Sir Henry Dale Fellowship from the Wellcome Trust/Royal Society (206234/Z/17/Z). Servier Medical Art (smart.servier.com) was used for the generation of some of the graphics. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

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Pulmonary macrophages and SARS-Cov2 infection. / Bain, Calum C ; Rossi, Adriano G ; Lucas, Christopher D.
International Review of Cell and Molecular Biology. ed. / Samanta A. Mariani; Luca Cassetta; Lorenzo Galluzzi. Vol. 367 Oxford, UK: Academic Press, 2022. (International Review of Cell and Molecular Biology).

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

TY - CHAP

T1 - Pulmonary macrophages and SARS-Cov2 infection

AU - Bain, Calum C

AU - Rossi, Adriano G

AU - Lucas, Christopher D

N1 - Funding Information: C.D.L. is funded by a Wellcome Trust Clinical Career Development Fellowship (206566/Z/17/Z). C.C.B. is funded by a Sir Henry Dale Fellowship from the Wellcome Trust/Royal Society (206234/Z/17/Z). Servier Medical Art (smart.servier.com) was used for the generation of some of the graphics. Publisher Copyright: © 2022 Elsevier Inc.

PY - 2022/4/20

Y1 - 2022/4/20

N2 - The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the largest global pandemic in living memory, with between 4.5 and 15M deaths globally from coronavirus disease 2019 (COVID-19). This has led to an unparalleled global, collaborative effort to understand the pathogenesis of this devastating disease using state-of-the-art technologies. A consistent feature of severe COVID-19 is dys- regulation of pulmonary macrophages, cells that under normal physiological conditions play vital roles in maintaining lung homeostasis and immunity. In this article, we will discuss a selection of the pivotal findings examining the role of monocytes and mac- rophages in SARS-CoV-2 infection and place this in context of recent advances made in understanding the fundamental immunobiology of these cells to try to understand how key homeostatic cells come to be a central pathogenic component of severe COVID-19 and key cells to target for therapeutic gain.

AB - The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the largest global pandemic in living memory, with between 4.5 and 15M deaths globally from coronavirus disease 2019 (COVID-19). This has led to an unparalleled global, collaborative effort to understand the pathogenesis of this devastating disease using state-of-the-art technologies. A consistent feature of severe COVID-19 is dys- regulation of pulmonary macrophages, cells that under normal physiological conditions play vital roles in maintaining lung homeostasis and immunity. In this article, we will discuss a selection of the pivotal findings examining the role of monocytes and mac- rophages in SARS-CoV-2 infection and place this in context of recent advances made in understanding the fundamental immunobiology of these cells to try to understand how key homeostatic cells come to be a central pathogenic component of severe COVID-19 and key cells to target for therapeutic gain.

KW - lung

KW - macrophage

KW - coronavirus

KW - SARS-CoV-2

U2 - 10.1016/bs.ircmb.2022.01.001

DO - 10.1016/bs.ircmb.2022.01.001

M3 - Chapter (peer-reviewed)

VL - 367

T3 - International Review of Cell and Molecular Biology

BT - International Review of Cell and Molecular Biology

A2 - Mariani, Samanta A.

A2 - Cassetta, Luca

A2 - Galluzzi, Lorenzo

PB - Academic Press

CY - Oxford, UK

ER -

Pulmonary macrophages and SARS-Cov2 infection

Abstract / Description of output

Publication series

Keywords / Materials (for Non-textual outputs)

Access to Document

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Projects

Investigating the role of TGF¿¿ in the functional imprinting of pulmonary macrophages in health and disease

Macrophage-epithelial communication promotes lung repair after injury

Cite this